Enhanced Attention-Driven Dynamic Graph Convolutional Network for Extracting Drug-Drug Interaction

Abstract

Automatically extracting Drug-Drug Interactions (DDIs) from text is a crucial and challenging task, particularly when multiple medications are taken concurrently. In this study, we propose a novel approach, called Enhanced Attention-driven Dynamic Graph Convolutional Network (E-ADGCN), for DDI extraction. Our model combines the Attention-driven Dynamic Graph Convolutional Network (ADGCN) with a feature fusion method and multi-task learning framework. The ADGCN effectively utilizes entity information and dependency tree information from biomedical texts to extract DDIs. The feature fusion method integrates User-Generated Content (UGC) and molecular information with drug entity information from text through dynamic routing. By leveraging external resources, our approach maximizes the auxiliary effect and improves the accuracy of DDI extraction. We evaluate the E-ADGCN model on the extended DDIExtraction2013 dataset and achieve an F1-score of 81.45%. This research contributes to the advancement of automated methods for extracting valuable drug interaction information from textual sources, facilitating improved medication management and patient safety.

Keywords

• drug-drug interaction (ddi)
• attention mechanism
• graph convolutional network (gcn)
• dynamic routing