Microbiota substances modulate dendritic cells activity: A critical view
Yuliia Shvets,
Natalia Khranovska,
Natalia Senchylo,
Danylo Ostapchenko,
Iryna Tymoshenko,
Svitlana Onysenko,
Nazarii Kobyliak,
Tetyana Falalyeyeva
Affiliations
Yuliia Shvets
Taras Shevchenko National University of Kyiv, 64/13 Volodymyrska Str., Kyiv, Ukraine; Corresponding author. Taras Shevchenko National University of Kyiv, Ukraine.
Natalia Khranovska
National Cancer Institute of Ukraine, 33/43 Yuliia Zdanovska Str., Kyiv, Ukraine
Natalia Senchylo
Taras Shevchenko National University of Kyiv, 64/13 Volodymyrska Str., Kyiv, Ukraine
Danylo Ostapchenko
Taras Shevchenko National University of Kyiv, 64/13 Volodymyrska Str., Kyiv, Ukraine
Iryna Tymoshenko
Bogomolets National Medical University, 13 Shevchenka Blvd., Kyiv, Ukraine
Svitlana Onysenko
Taras Shevchenko National University of Kyiv, 64/13 Volodymyrska Str., Kyiv, Ukraine
Nazarii Kobyliak
Bogomolets National Medical University, 13 Shevchenka Blvd., Kyiv, Ukraine; Medical Laboratory CSD, 22b Zhmerynska Str., Kyiv, Ukraine; Corresponding author. Bogomolets National Medical University, Kyiv, Ukraine.
Tetyana Falalyeyeva
Taras Shevchenko National University of Kyiv, 64/13 Volodymyrska Str., Kyiv, Ukraine; Medical Laboratory CSD, 22b Zhmerynska Str., Kyiv, Ukraine
Contemporary research in the field of microbiota shows that commensal bacteria influence physiological activity of different organs and systems of a human organism, such as brain, lungs, immune and metabolic systems. This influence is realized by various processes. One of them is trough modulation of immune mechanisms. Interactions between microbiota and the human immune system are known to be complex and ambiguous. Dendritic cells (DCs) are unique cells, which initiate the development and polarization of adaptive immune response. These cells also interconnect native and specific immune reactivity. A large set of biochemical signals from microbiota in the form of different microbiota associated molecular patterns (MAMPs) and bacterial metabolites that act locally and distantly in the human organism. As a result, commensal bacteria influence the maturity and activity of dendritic cells and affect the overall immune reactivity of the human organism. It then determines the response to pathogenic microorganisms, inflammation, associated with different pathological conditions and even affects the effectiveness of vaccination.
