Spatiotemporal dynamics of macrophage heterogeneity and a potential function of Trem2hi macrophages in infarcted hearts

Seung-Hyun Jung; Byung-Hee Hwang; Sun Shin; Eun-Hye Park; Sin-Hee Park; Chan Woo Kim; Eunmin Kim; Eunho Choo; Ik Jun Choi; Filip K. Swirski; Kiyuk Chang; Yeun-Jun Chung

doi:10.1038/s41467-022-32284-2

Nature Communications (Aug 2022)

Spatiotemporal dynamics of macrophage heterogeneity and a potential function of Trem2hi macrophages in infarcted hearts

Seung-Hyun Jung,
Byung-Hee Hwang,
Sun Shin,
Eun-Hye Park,
Sin-Hee Park,
Chan Woo Kim,
Eunmin Kim,
Eunho Choo,
Ik Jun Choi,
Filip K. Swirski,
Kiyuk Chang,
Yeun-Jun Chung

Affiliations

Seung-Hyun Jung: Department of Biochemistry, College of Medicine, The Catholic University of Korea
Byung-Hee Hwang: Cardiovascular Research Institute for Intractable Disease, College of Medicine, The Catholic University of Korea
Sun Shin: Departments of Microbiology, IRCGP, Cancer Evolution Research Center, College of Medicine, The Catholic University of Korea
Eun-Hye Park: Cardiovascular Research Institute for Intractable Disease, College of Medicine, The Catholic University of Korea
Sin-Hee Park: Cardiovascular Research Institute for Intractable Disease, College of Medicine, The Catholic University of Korea
Chan Woo Kim: Cardiovascular Research Institute for Intractable Disease, College of Medicine, The Catholic University of Korea
Eunmin Kim: Cardiovascular Research Institute for Intractable Disease, College of Medicine, The Catholic University of Korea
Eunho Choo: Cardiovascular Research Institute for Intractable Disease, College of Medicine, The Catholic University of Korea
Ik Jun Choi: Division of Cardiology, Incheon St. Mary’s Hospital, College of Medicine, The Catholic University of Korea
Filip K. Swirski: Cardiovascular Research Institute, Icahn School of Medicine at Mount Sinai
Kiyuk Chang: Cardiovascular Research Institute for Intractable Disease, College of Medicine, The Catholic University of Korea
Yeun-Jun Chung: Department of Biomedicine & Health Sciences, College of Medicine, The Catholic University of Korea

DOI: https://doi.org/10.1038/s41467-022-32284-2
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 15

Abstract

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Cellular composition and function are not clearly defined in heart failure after myocardial infarction. Here, using single cell and spatial transcriptomics in a MI-HF mouse model, the authors show that macrophages expressing Trem2 are found within the infarcts and this could be a useful biomarker.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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