Systematic allelic analysis defines the interplay of key pathways in X chromosome inactivation

Tatyana B. Nesterova; Guifeng Wei; Heather Coker; Greta Pintacuda; Joseph S. Bowness; Tianyi Zhang; Mafalda Almeida; Bianca Bloechl; Benoit Moindrot; Emma J. Carter; Ines Alvarez Rodrigo; Qi Pan; Ying Bi; Chun-Xiao Song; Neil Brockdorff

doi:10.1038/s41467-019-11171-3

Nature Communications (Jul 2019)

Systematic allelic analysis defines the interplay of key pathways in X chromosome inactivation

Tatyana B. Nesterova,
Guifeng Wei,
Heather Coker,
Greta Pintacuda,
Joseph S. Bowness,
Tianyi Zhang,
Mafalda Almeida,
Bianca Bloechl,
Benoit Moindrot,
Emma J. Carter,
Ines Alvarez Rodrigo,
Qi Pan,
Ying Bi,
Chun-Xiao Song,
Neil Brockdorff

Affiliations

Tatyana B. Nesterova: Developmental Epigenetics, Department of Biochemistry, University of Oxford
Guifeng Wei: Developmental Epigenetics, Department of Biochemistry, University of Oxford
Heather Coker: Developmental Epigenetics, Department of Biochemistry, University of Oxford
Greta Pintacuda: Developmental Epigenetics, Department of Biochemistry, University of Oxford
Joseph S. Bowness: Developmental Epigenetics, Department of Biochemistry, University of Oxford
Tianyi Zhang: Developmental Epigenetics, Department of Biochemistry, University of Oxford
Mafalda Almeida: Developmental Epigenetics, Department of Biochemistry, University of Oxford
Bianca Bloechl: Developmental Epigenetics, Department of Biochemistry, University of Oxford
Benoit Moindrot: Developmental Epigenetics, Department of Biochemistry, University of Oxford
Emma J. Carter: Developmental Epigenetics, Department of Biochemistry, University of Oxford
Ines Alvarez Rodrigo: Developmental Epigenetics, Department of Biochemistry, University of Oxford
Qi Pan: Developmental Epigenetics, Department of Biochemistry, University of Oxford
Ying Bi: Ludwig Institute for Cancer Research, Target Discovery Institute, Nuffield Department of Medicine, University of Oxford
Chun-Xiao Song: Ludwig Institute for Cancer Research, Target Discovery Institute, Nuffield Department of Medicine, University of Oxford
Neil Brockdorff: Developmental Epigenetics, Department of Biochemistry, University of Oxford

DOI: https://doi.org/10.1038/s41467-019-11171-3
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 15

Abstract

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Xist RNA is the master regulator of X chromosome inactivation. Here the authors describe a systematic analysis of Xist-mediated allelic silencing in mouse ESC models and define the contribution of different pathways that regulate gene silencing.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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