npj Biofilms and Microbiomes (Feb 2021)
Lung microbiota associations with clinical features of COPD in the SPIROMICS cohort
- Kristopher Opron,
- Lesa A. Begley,
- John R. Erb-Downward,
- Christine Freeman,
- Siddharth Madapoosi,
- Neil E. Alexis,
- Igor Barjaktarevic,
- R. Graham Barr,
- Eugene R. Bleecker,
- Russell P. Bowler,
- Stephanie A. Christenson,
- Alejandro P. Comellas,
- Christopher B. Cooper,
- David J. Couper,
- Claire M. Doerschuk,
- Mark T. Dransfield,
- MeiLan K. Han,
- Nadia N. Hansel,
- Annette T. Hastie,
- Eric A. Hoffman,
- Robert J. Kaner,
- Jerry Krishnan,
- Wanda K. O’Neal,
- Victor E. Ortega,
- Robert Paine,
- Stephen P. Peters,
- J. Michael Wells,
- Prescott G. Woodruff,
- Fernando J. Martinez,
- Jeffrey L. Curtis,
- Gary B. Huffnagle,
- Yvonne J. Huang
Affiliations
- Kristopher Opron
- Division of Pulmonary/Critical Care Medicine, University of Michigan
- Lesa A. Begley
- Division of Pulmonary/Critical Care Medicine, University of Michigan
- John R. Erb-Downward
- Division of Pulmonary/Critical Care Medicine, University of Michigan
- Christine Freeman
- Division of Pulmonary/Critical Care Medicine, University of Michigan
- Siddharth Madapoosi
- Division of Pulmonary/Critical Care Medicine, University of Michigan
- Neil E. Alexis
- University of North Carolina at Chapel Hill
- Igor Barjaktarevic
- University of California at Los Angeles
- R. Graham Barr
- Columbia University
- Eugene R. Bleecker
- University of Arizona College of Medicine
- Russell P. Bowler
- National Jewish Health
- Stephanie A. Christenson
- University of California at San Francisco
- Alejandro P. Comellas
- University of Iowa
- Christopher B. Cooper
- University of California at Los Angeles
- David J. Couper
- University of North Carolina at Chapel Hill
- Claire M. Doerschuk
- University of North Carolina at Chapel Hill
- Mark T. Dransfield
- University of Alabama at Birmingham
- MeiLan K. Han
- Division of Pulmonary/Critical Care Medicine, University of Michigan
- Nadia N. Hansel
- John Hopkins University
- Annette T. Hastie
- Wake Forest School of Medicine
- Eric A. Hoffman
- University of Iowa
- Robert J. Kaner
- Weill Cornell Medical College
- Jerry Krishnan
- University of Illinois
- Wanda K. O’Neal
- University of North Carolina at Chapel Hill
- Victor E. Ortega
- Wake Forest School of Medicine
- Robert Paine
- University of Utah
- Stephen P. Peters
- Wake Forest School of Medicine
- J. Michael Wells
- University of Alabama at Birmingham
- Prescott G. Woodruff
- University of California at San Francisco
- Fernando J. Martinez
- Weill Cornell Medical College
- Jeffrey L. Curtis
- Division of Pulmonary/Critical Care Medicine, University of Michigan
- Gary B. Huffnagle
- Division of Pulmonary/Critical Care Medicine, University of Michigan
- Yvonne J. Huang
- Division of Pulmonary/Critical Care Medicine, University of Michigan
- DOI
- https://doi.org/10.1038/s41522-021-00185-9
- Journal volume & issue
-
Vol. 7,
no. 1
pp. 1 – 10
Abstract
Abstract Chronic obstructive pulmonary disease (COPD) is heterogeneous in development, progression, and phenotypes. Little is known about the lung microbiome, sampled by bronchoscopy, in milder COPD and its relationships to clinical features that reflect disease heterogeneity (lung function, symptom burden, and functional impairment). Using bronchoalveolar lavage fluid collected from 181 never-smokers and ever-smokers with or without COPD (GOLD 0-2) enrolled in the SubPopulations and InteRmediate Outcome Measures In COPD Study (SPIROMICS), we find that lung bacterial composition associates with several clinical features, in particular bronchodilator responsiveness, peak expiratory flow rate, and forced expiratory flow rate between 25 and 75% of FVC (FEF25–75). Measures of symptom burden (COPD Assessment Test) and functional impairment (six-minute walk distance) also associate with disparate lung microbiota composition. Drivers of these relationships include members of the Streptococcus, Prevotella, Veillonella, Staphylococcus, and Pseudomonas genera. Thus, lung microbiota differences may contribute to airway dysfunction and airway disease in milder COPD.
