Nature Communications (Apr 2023)
Retinoic acid signaling modulation guides in vitro specification of human heart field-specific progenitor pools
- Dorota Zawada,
- Jessica Kornherr,
- Anna B. Meier,
- Gianluca Santamaria,
- Tatjana Dorn,
- Monika Nowak-Imialek,
- Daniel Ortmann,
- Fangfang Zhang,
- Mark Lachmann,
- Martina Dreßen,
- Mariaestela Ortiz,
- Victoria L. Mascetti,
- Stephen C. Harmer,
- Muriel Nobles,
- Andrew Tinker,
- Maria Teresa De Angelis,
- Roger A. Pedersen,
- Phillip Grote,
- Karl-Ludwig Laugwitz,
- Alessandra Moretti,
- Alexander Goedel
Affiliations
- Dorota Zawada
- First Department of Medicine, Cardiology, Klinikum rechts der Isar, Technical University of Munich, School of Medicine and Health
- Jessica Kornherr
- First Department of Medicine, Cardiology, Klinikum rechts der Isar, Technical University of Munich, School of Medicine and Health
- Anna B. Meier
- First Department of Medicine, Cardiology, Klinikum rechts der Isar, Technical University of Munich, School of Medicine and Health
- Gianluca Santamaria
- First Department of Medicine, Cardiology, Klinikum rechts der Isar, Technical University of Munich, School of Medicine and Health
- Tatjana Dorn
- First Department of Medicine, Cardiology, Klinikum rechts der Isar, Technical University of Munich, School of Medicine and Health
- Monika Nowak-Imialek
- First Department of Medicine, Cardiology, Klinikum rechts der Isar, Technical University of Munich, School of Medicine and Health
- Daniel Ortmann
- Department of Surgery, University of Cambridge
- Fangfang Zhang
- First Department of Medicine, Cardiology, Klinikum rechts der Isar, Technical University of Munich, School of Medicine and Health
- Mark Lachmann
- First Department of Medicine, Cardiology, Klinikum rechts der Isar, Technical University of Munich, School of Medicine and Health
- Martina Dreßen
- German Heart Center Munich, Department of Cardiovascular Surgery, Institute Insure - Technical University of Munich, School of Medicine and Health
- Mariaestela Ortiz
- Department of Surgery, University of Cambridge
- Victoria L. Mascetti
- Bristol Heart Institute, Bristol Medical School, Translational Health Sciences
- Stephen C. Harmer
- School of Physiology, Pharmacology and Neuroscience, Faculty of Life Sciences, University of Bristol
- Muriel Nobles
- Clinical Pharmacology & Precision Medicine, William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London
- Andrew Tinker
- Clinical Pharmacology & Precision Medicine, William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London
- Maria Teresa De Angelis
- First Department of Medicine, Cardiology, Klinikum rechts der Isar, Technical University of Munich, School of Medicine and Health
- Roger A. Pedersen
- Department of Obstetrics and Gynecology, Stanford School of Medicine, Stanford University
- Phillip Grote
- Georg-Speyer-Haus, Institute for Tumor Biology and Experimental Therapy
- Karl-Ludwig Laugwitz
- First Department of Medicine, Cardiology, Klinikum rechts der Isar, Technical University of Munich, School of Medicine and Health
- Alessandra Moretti
- First Department of Medicine, Cardiology, Klinikum rechts der Isar, Technical University of Munich, School of Medicine and Health
- Alexander Goedel
- First Department of Medicine, Cardiology, Klinikum rechts der Isar, Technical University of Munich, School of Medicine and Health
- DOI
- https://doi.org/10.1038/s41467-023-36764-x
- Journal volume & issue
-
Vol. 14,
no. 1
pp. 1 – 20
Abstract
The heart is formed from several spatiotemporally distinct progenitor pools during development. Here they show that modulation of retinoic acid signaling can instruct human pluripotent stems cells into heart progenitors that are useful for studying human development and disease.
