Nature Communications (Mar 2017)

Direct amidation of esters with nitroarenes

  • Chi Wai Cheung,
  • Marten Leendert Ploeger,
  • Xile Hu

DOI
https://doi.org/10.1038/ncomms14878
Journal volume & issue
Vol. 8, no. 1
pp. 1 – 10

Abstract

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Direct conversion of esters to amides, while attractive, is often limited to activated esters or highly nucleophilic amines. Here the authors report a nickel-catalysed reductive coupling between unactivated esters and nitroarenes, giving a direct route to aromatic amides.