New glance at pathogenesis of type 2 diabetes mellitus: incretin and antiincretin systems.

Abstract

Type 2 diabetes mellitus (T2 DM) is often seen in patients with obesity. Bariatric surgery, aimed to decrease body weight, can often help those patientsto improve glycemic status. After some of bariatric operations patients reach normoglycemia in few days, the fact that cant be explained onlyby reduction in weight. Recent trials revealed that the reorganization of gastrointestinal tract provides hypoglycemic effect of such operations. Thisarticle explains the role of proximal and distal gut in pathophysiology of T2 DM.

Keywords

• glucagon
• glucagon-like peptide
• glucose-dependent insulinotropic polypeptide
• bariatric surgery
• incretins
• type 2 diabetes mellitus