Epigenome-wide meta-analysis of DNA methylation differences in prefrontal cortex implicates the immune processes in Alzheimer’s disease

Lanyu Zhang; Tiago C. Silva; Juan I. Young; Lissette Gomez; Michael A. Schmidt; Kara L. Hamilton-Nelson; Brian W. Kunkle; Xi Chen; Eden R. Martin; Lily Wang

doi:10.1038/s41467-020-19791-w

Nature Communications (Nov 2020)

Epigenome-wide meta-analysis of DNA methylation differences in prefrontal cortex implicates the immune processes in Alzheimer’s disease

Lanyu Zhang,
Tiago C. Silva,
Juan I. Young,
Lissette Gomez,
Michael A. Schmidt,
Kara L. Hamilton-Nelson,
Brian W. Kunkle,
Xi Chen,
Eden R. Martin,
Lily Wang

Affiliations

Lanyu Zhang: Division of Biostatistics, Department of Public Health Sciences, Miller School of Medicine, University of Miami
Tiago C. Silva: Division of Biostatistics, Department of Public Health Sciences, Miller School of Medicine, University of Miami
Juan I. Young: Dr. John T Macdonald Foundation Department of Human Genetics, Miller School of Medicine, University of Miami
Lissette Gomez: John P. Hussman Institute for Human Genomics, Miller School of Medicine, University of Miami
Michael A. Schmidt: Dr. John T Macdonald Foundation Department of Human Genetics, Miller School of Medicine, University of Miami
Kara L. Hamilton-Nelson: John P. Hussman Institute for Human Genomics, Miller School of Medicine, University of Miami
Brian W. Kunkle: Dr. John T Macdonald Foundation Department of Human Genetics, Miller School of Medicine, University of Miami
Xi Chen: Division of Biostatistics, Department of Public Health Sciences, Miller School of Medicine, University of Miami
Eden R. Martin: Dr. John T Macdonald Foundation Department of Human Genetics, Miller School of Medicine, University of Miami
Lily Wang: Division of Biostatistics, Department of Public Health Sciences, Miller School of Medicine, University of Miami

DOI: https://doi.org/10.1038/s41467-020-19791-w
Journal volume & issue: Vol. 11, no. 1
pp. 1 – 13

Abstract

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Previous studies have identified DNA methylation changes in Alzheimer’s disease. Here the authors perform a meta-analysis of DNA methylation datasets to identify epigenetic correlates of Alzheimer’s disease in the prefrontal cortex.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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