Diester Chlorogenoborate Complex: A New Naturally Occurring Boron-Containing Compound
Andrei Biţă,
Ion Romulus Scorei,
Nagendra Rangavajla,
Ludovic Everard Bejenaru,
Gabriela Rău,
Cornelia Bejenaru,
Maria Viorica Ciocîlteu,
Laura Dincă,
Johny Neamţu,
Andrei Bunaciu,
Otilia Constantina Rogoveanu,
Mihai Ioan Pop,
George Dan Mogoşanu
Affiliations
Andrei Biţă
Department of Biochemistry, BioBoron Research Institute, S.C. Natural Research S.R.L., 31B Dunării Street, Dolj County, 207465 Podari, Romania
Ion Romulus Scorei
Department of Biochemistry, BioBoron Research Institute, S.C. Natural Research S.R.L., 31B Dunării Street, Dolj County, 207465 Podari, Romania
Nagendra Rangavajla
Califia Farms, 1321 Palmetto Street, Los Angeles, CA 90013, USA
Ludovic Everard Bejenaru
Department of Pharmacognosy & Phytotherapy, Faculty of Pharmacy, University of Medicine and Pharmacy of Craiova, 2 Petru Rareş Street, Dolj County, 200349 Craiova, Romania
Gabriela Rău
Department of Biochemistry, BioBoron Research Institute, S.C. Natural Research S.R.L., 31B Dunării Street, Dolj County, 207465 Podari, Romania
Cornelia Bejenaru
Department of Pharmaceutical Botany, Faculty of Pharmacy, University of Medicine and Pharmacy of Craiova, 2 Petru Rareş Street, Dolj County, 200349 Craiova, Romania
Maria Viorica Ciocîlteu
Department of Biochemistry, BioBoron Research Institute, S.C. Natural Research S.R.L., 31B Dunării Street, Dolj County, 207465 Podari, Romania
Laura Dincă
Department of Biochemistry, BioBoron Research Institute, S.C. Natural Research S.R.L., 31B Dunării Street, Dolj County, 207465 Podari, Romania
Johny Neamţu
Department of Biochemistry, BioBoron Research Institute, S.C. Natural Research S.R.L., 31B Dunării Street, Dolj County, 207465 Podari, Romania
Andrei Bunaciu
S.C. AAB_IR Research S.R.L., 9–11A Gloriei Street, Ilfov County, 077025 Bragadiru, Romania
Otilia Constantina Rogoveanu
Department of Physical Medicine and Rehabilitation, University of Medicine and Pharmacy of Craiova, 2 Petru Rareş Street, Dolj County, 200349 Craiova, Romania
Mihai Ioan Pop
Faculty of Medical Sciences, University College London, Gower Street, Bloomsbury, London WC1E 6AB, UK
George Dan Mogoşanu
Department of Biochemistry, BioBoron Research Institute, S.C. Natural Research S.R.L., 31B Dunării Street, Dolj County, 207465 Podari, Romania
The natural compounds of boron have many applications, primarily as a dietary supplement. The research is based on the discovery that the diester chlorogenoborate complex can be detected and quantified from green coffee beans. The study reports that such a diester molecule can also be synthesized in a stable form via the direct reaction of boric acid and chlorogenic acid in a mixture of acetonitrile–water (1:1, v/v) and left to evaporate over a period of 48 h at room temperature, resulting in a spirocyclic form (diester complex). The diester complex, with its molecular structure and digestibility attributes, has potential application as a prebiotic in gut health and oral health, and as a micronutrient essential for microbiota in humans and animals.
