Gelsolin regulates proliferation, apoptosis and invasion in natural killer/T-cell lymphoma cells

Abstract

The expression of gelsolin (GSN) is abnormal in many cancers, including extranodal nasal-type natural killer/T-cell lymphoma (NKTCL). However, the biological function of GSN and its mechanism in NKTCL remain unclear. We found that GSN overexpression significantly suppressed cell proliferation, colony formation and invasion, and promoted apoptosis of natural killer (NK) cell line YTS. Moreover, the upregulation of GSN significantly decreased the levels of PI3K and p-Akt. Interestingly, blocking the PI3K/Akt signaling pathway significantly inhibited cell proliferation and invasion and promoted apoptosis of YTS cells. In conclusion, our findings indicate that GSN can suppress cell proliferation and invasion and promote apoptosis of YTS cells, and the PI3K/Akt signaling pathway is likely to be involved in this process.

Keywords

• Gelsolin
• NK/T-cell lymphoma cell
• Cell proliferation
• Apoptosis
• Invasion