Future Science OA (Jun 2022)

Prognostic value of circulating endothelial cells in glioblastoma patients: a pilot study

  • María Angeles Vaz Salgado,
  • Julie Earl,
  • Victor Rodriguez Berrocal,
  • Freddy Salge Arrieta,
  • Ana Gomez,
  • Juan Manuel Sepulveda-Sanchez,
  • Ángel Perez-Nuñez,
  • Elena Corral de la Fuente,
  • Daniel Lourido,
  • MaríaVillamayor,
  • Hector Pian,
  • Alfonso Muriel,
  • Elisabetta Rossi,
  • Rita Zamarchi,
  • Alfredo Carrato,
  • Luis Ley

DOI
https://doi.org/10.2144/fsoa-2022-0008
Journal volume & issue
Vol. 8, no. 5

Abstract

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Aim: Glioblastoma (GB) is an aggressive tumor type and the detection of circulating endothelial cells (CECs) in peripheral blood has been related to angiogenesis. Materials & methods: A prospective single-center pilot study of CEC detection at diagnosis in 22 patients with GB was performed, using the US FDA-approved CellSearch system. Results: A CEC cutoff value was estimated using a receiver operating curve (ROC) and patients were classified into two groups: 40 CEC/4 ml blood. Median overall survival was 25.33 months for group 1 and 8.23 months for group 2 cases (p = 0.02). There was no correlation between CEC and PWI (perfusion-weighted imaging) RM. Conclusion: CEC detection has a prognostic value in GB cases at diagnosis.

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