Prognostic value of circulating endothelial cells in glioblastoma patients: a pilot study

María Angeles Vaz Salgado; Julie Earl; Victor Rodriguez Berrocal; Freddy Salge Arrieta; Ana Gomez; Juan Manuel Sepulveda-Sanchez; Ángel Perez-Nuñez; Elena Corral de la Fuente; Daniel Lourido; MaríaVillamayor; Hector Pian; Alfonso Muriel; Elisabetta Rossi; Rita Zamarchi; Alfredo Carrato; Luis Ley

doi:10.2144/fsoa-2022-0008

Future Science OA (Jun 2022)

Prognostic value of circulating endothelial cells in glioblastoma patients: a pilot study

María Angeles Vaz Salgado,
Julie Earl,
Victor Rodriguez Berrocal,
Freddy Salge Arrieta,
Ana Gomez,
Juan Manuel Sepulveda-Sanchez,
Ángel Perez-Nuñez,
Elena Corral de la Fuente,
Daniel Lourido,
MaríaVillamayor,
Hector Pian,
Alfonso Muriel,
Elisabetta Rossi,
Rita Zamarchi,
Alfredo Carrato,
Luis Ley

Affiliations

María Angeles Vaz Salgado: 1Medical Oncology Department. Ramón y Cajal Hospital. IRYCIS, CIBERONC, Madrid, 28034, Spain
Julie Earl: 1Medical Oncology Department. Ramón y Cajal Hospital. IRYCIS, CIBERONC, Madrid, 28034, Spain
Victor Rodriguez Berrocal: 2Neurosurgery Department. Ramón y Cajal Hospital, Madrid, 28034, Spain
Freddy Salge Arrieta: 2Neurosurgery Department. Ramón y Cajal Hospital, Madrid, 28034, Spain
Ana Gomez: 1Medical Oncology Department. Ramón y Cajal Hospital. IRYCIS, CIBERONC, Madrid, 28034, Spain
Juan Manuel Sepulveda-Sanchez: 3Medical Oncology Department. 12 de Octubre Hospital. Instituto de Investigación I+12, Madrid, 28041, Spain
Ángel Perez-Nuñez: 4Neurosurgery Department. 12 de Octubre Hospital, Madrid, 28034, Spain
Elena Corral de la Fuente: 1Medical Oncology Department. Ramón y Cajal Hospital. IRYCIS, CIBERONC, Madrid, 28034, Spain
Daniel Lourido: 5Radiology Department. Ramón y Cajal Hospital, Madrid, 28034, Spain
MaríaVillamayor: 1Medical Oncology Department. Ramón y Cajal Hospital. IRYCIS, CIBERONC, Madrid, 28034, Spain
Hector Pian: 6Pathology Department, Ramón y Cajal Hospital, Madrid, 28034, Spain
Alfonso Muriel: 7Clinical Biostatistic Unit, Hospital Universitario Ramón y Cajal, IRYCIS, CIBERESP, Nursing Department Universidad de Alcalá Madrid, 28034, Spain
Elisabetta Rossi: 8Department of Surgery, Oncology & Gastroenterology, University of Padova, Padua, 35124, Italy
Rita Zamarchi: 9Veneto Institute of Oncology IOV – IRCCS, Padua, 35128, Italy
Alfredo Carrato: 1Medical Oncology Department. Ramón y Cajal Hospital. IRYCIS, CIBERONC, Madrid, 28034, Spain
Luis Ley: 2Neurosurgery Department. Ramón y Cajal Hospital, Madrid, 28034, Spain

DOI: https://doi.org/10.2144/fsoa-2022-0008
Journal volume & issue: Vol. 8, no. 5

Abstract

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Aim: Glioblastoma (GB) is an aggressive tumor type and the detection of circulating endothelial cells (CECs) in peripheral blood has been related to angiogenesis. Materials & methods: A prospective single-center pilot study of CEC detection at diagnosis in 22 patients with GB was performed, using the US FDA-approved CellSearch system. Results: A CEC cutoff value was estimated using a receiver operating curve (ROC) and patients were classified into two groups: 40 CEC/4 ml blood. Median overall survival was 25.33 months for group 1 and 8.23 months for group 2 cases (p = 0.02). There was no correlation between CEC and PWI (perfusion-weighted imaging) RM. Conclusion: CEC detection has a prognostic value in GB cases at diagnosis.

Published in Future Science OA

ISSN: 2056-5623 (Online)
Publisher: Taylor & Francis Group
Country of publisher: United Kingdom
LCC subjects: Medicine: Medicine (General)
Website: https://www.tandfonline.com/journals/ifso20

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