Zhongguo linchuang yanjiu (Jan 2024)

Risk factors associated with severe coronavirus disease 2019 in maintenance hemodialysis patients

  • DONG Chunli, SONG Haitao, YU Xin, LI Zhenxiao, WANG Yongjie

DOI
https://doi.org/10.13429/j.cnki.cjcr.2024.01.016
Journal volume & issue
Vol. 37, no. 1
pp. 75 – 78

Abstract

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Objective: To analyze the risk factors of severe coronavirus disease 2019 (COVID-19) in maintenance hemodialysis patients, and provide reference for early risk identification of the patients. Method: The clinical data of 73 maintenance hemodialysis patients diagnosed with COVID-19 admitted to Jilin Province People's Hospital from March to April 2022 were restrospectinely collected, and the patients were divided into MC group (mild and ordinary type, n=61) and SC group (severe and critically severe type, n=12) based on clinical classification. The patients' baseline data [age, gender, COVID-19 vaccination status, age adjusted Charlson's complication index (aCCI), primary hypertension, diabetes, coronary heart disease, malignant tumor, dialysis time], first clinical symptoms (fever, dry cough, fatigue, sore throat, diarrhea, dyspnea) and laboratory examination indexes within 24 hours of admission (total number of white blood cells, neutrophils and lymphocytes; C-reactive protein, procalcitonin, D-dimer, albumin) were collected. Multivariate logistic regression analysis was used to identify the risk factors for severe COVID-19 in maintenance hemodialysis patients. Results: There were statistically significant differences in age, aCCI, total lymphocyte count, C-reactive protein and D-dimer between the two groups (P<0.01). Multivariate logistic regression analysis showed that older age and higher C-reactive protein level were the independent risk factors for severe COVID-19 in maintenance hemodialysis patients (OR=1.256, 95%CI:1.016-1.553, P=0.035; OR=1.021, 95%CI: 1.001-1.041, P=0.041). Conclusion: The COVID-19 vaccination rate of maintenance hemodialysis patients is low, the overall age is older. Older age and higher level of C-reactive protein are independent risk factors for severe COVID-19 in maintenance hemodialysis patients.

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