Nature Communications (Jan 2020)
IgA subclasses have different effector functions associated with distinct glycosylation profiles
- Ulrike Steffen,
- Carolien A. Koeleman,
- Maria V. Sokolova,
- Holger Bang,
- Arnd Kleyer,
- Jürgen Rech,
- Harald Unterweger,
- Martin Schicht,
- Fabian Garreis,
- Jonas Hahn,
- Fabian T. Andes,
- Fabian Hartmann,
- Madelaine Hahn,
- Aparna Mahajan,
- Friedrich Paulsen,
- Markus Hoffmann,
- Günter Lochnit,
- Luis E. Muñoz,
- Manfred Wuhrer,
- David Falck,
- Martin Herrmann,
- Georg Schett
Affiliations
- Ulrike Steffen
- Department of Internal Medicine 3—Rheumatology and Immunology, Friedrich-Alexander-University Erlangen-Nürnberg (FAU) and Universitätsklinikum Erlangen
- Carolien A. Koeleman
- Leiden University Medical Center, Center for Proteomics and Metabolomics, Glycomics and Clinical Proteomics Group
- Maria V. Sokolova
- Department of Internal Medicine 3—Rheumatology and Immunology, Friedrich-Alexander-University Erlangen-Nürnberg (FAU) and Universitätsklinikum Erlangen
- Holger Bang
- Orgentec Diagnostika
- Arnd Kleyer
- Department of Internal Medicine 3—Rheumatology and Immunology, Friedrich-Alexander-University Erlangen-Nürnberg (FAU) and Universitätsklinikum Erlangen
- Jürgen Rech
- Department of Internal Medicine 3—Rheumatology and Immunology, Friedrich-Alexander-University Erlangen-Nürnberg (FAU) and Universitätsklinikum Erlangen
- Harald Unterweger
- Section of Experimental Oncology and Nanomedicine (SEON), ENT Department, Friedrich-Alexander-University Erlangen-Nürnberg (FAU) and Universitätsklinikum Erlangen
- Martin Schicht
- Institute of Functional and Clinical Anatomy, Friedrich Alexander University Erlangen-Nürnberg
- Fabian Garreis
- Institute of Functional and Clinical Anatomy, Friedrich Alexander University Erlangen-Nürnberg
- Jonas Hahn
- Department of Internal Medicine 3—Rheumatology and Immunology, Friedrich-Alexander-University Erlangen-Nürnberg (FAU) and Universitätsklinikum Erlangen
- Fabian T. Andes
- Department of Internal Medicine 3—Rheumatology and Immunology, Friedrich-Alexander-University Erlangen-Nürnberg (FAU) and Universitätsklinikum Erlangen
- Fabian Hartmann
- Department of Internal Medicine 3—Rheumatology and Immunology, Friedrich-Alexander-University Erlangen-Nürnberg (FAU) and Universitätsklinikum Erlangen
- Madelaine Hahn
- Department of Internal Medicine 3—Rheumatology and Immunology, Friedrich-Alexander-University Erlangen-Nürnberg (FAU) and Universitätsklinikum Erlangen
- Aparna Mahajan
- Department of Internal Medicine 3—Rheumatology and Immunology, Friedrich-Alexander-University Erlangen-Nürnberg (FAU) and Universitätsklinikum Erlangen
- Friedrich Paulsen
- Institute of Functional and Clinical Anatomy, Friedrich Alexander University Erlangen-Nürnberg
- Markus Hoffmann
- Department of Internal Medicine 3—Rheumatology and Immunology, Friedrich-Alexander-University Erlangen-Nürnberg (FAU) and Universitätsklinikum Erlangen
- Günter Lochnit
- Protein Analytics, Institute of Biochemistry, Faculty of Medicine, Justus-Liebig-University Giessen
- Luis E. Muñoz
- Department of Internal Medicine 3—Rheumatology and Immunology, Friedrich-Alexander-University Erlangen-Nürnberg (FAU) and Universitätsklinikum Erlangen
- Manfred Wuhrer
- Leiden University Medical Center, Center for Proteomics and Metabolomics, Glycomics and Clinical Proteomics Group
- David Falck
- Leiden University Medical Center, Center for Proteomics and Metabolomics, Glycomics and Clinical Proteomics Group
- Martin Herrmann
- Department of Internal Medicine 3—Rheumatology and Immunology, Friedrich-Alexander-University Erlangen-Nürnberg (FAU) and Universitätsklinikum Erlangen
- Georg Schett
- Department of Internal Medicine 3—Rheumatology and Immunology, Friedrich-Alexander-University Erlangen-Nürnberg (FAU) and Universitätsklinikum Erlangen
- DOI
- https://doi.org/10.1038/s41467-019-13992-8
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 12
Abstract
Immunoglobulin A (IgA) has two subclasses, IgA1 and IgA2, but differential effects on inflammation are unclear. Here the authors show that IgA2, when compared with IgA1, has stronger pro-inflammatory functions associated with changed glycosylation and higher disease scores in patients with rheumatoid arthritis.
