Nature Communications (Apr 2018)
Cooperative STAT/NF-κB signaling regulates lymphoma metabolic reprogramming and aberrant GOT2 expression
- Maren Feist,
- Philipp Schwarzfischer,
- Paul Heinrich,
- Xueni Sun,
- Judith Kemper,
- Frederike von Bonin,
- Paula Perez-Rubio,
- Franziska Taruttis,
- Thorsten Rehberg,
- Katja Dettmer,
- Wolfram Gronwald,
- Jörg Reinders,
- Julia C. Engelmann,
- Jan Dudek,
- Wolfram Klapper,
- Lorenz Trümper,
- Rainer Spang,
- Peter J. Oefner,
- Dieter Kube
Affiliations
- Maren Feist
- Clinic of Haematology and Medical Oncology, University Medical Centre Göttingen
- Philipp Schwarzfischer
- Network BMBF eBio MMML MYC-SYS
- Paul Heinrich
- Institute of Functional Genomics, University of Regensburg
- Xueni Sun
- Institute of Functional Genomics, University of Regensburg
- Judith Kemper
- Clinic of Haematology and Medical Oncology, University Medical Centre Göttingen
- Frederike von Bonin
- Clinic of Haematology and Medical Oncology, University Medical Centre Göttingen
- Paula Perez-Rubio
- Network BMBF eMed MMML-Demonstrators
- Franziska Taruttis
- Network BMBF eBio MMML MYC-SYS
- Thorsten Rehberg
- Statistical Bioinformatics, Institute of Functional Genomics, University of Regensburg
- Katja Dettmer
- Institute of Functional Genomics, University of Regensburg
- Wolfram Gronwald
- Network BMBF eBio MMML MYC-SYS
- Jörg Reinders
- Institute of Functional Genomics, University of Regensburg
- Julia C. Engelmann
- Network BMBF eBio MMML MYC-SYS
- Jan Dudek
- Institute of Biochemistry, University Medical Centre Göttingen
- Wolfram Klapper
- Network BMBF eBio MMML MYC-SYS
- Lorenz Trümper
- Clinic of Haematology and Medical Oncology, University Medical Centre Göttingen
- Rainer Spang
- Network BMBF eBio MMML MYC-SYS
- Peter J. Oefner
- Institute of Functional Genomics, University of Regensburg
- Dieter Kube
- Clinic of Haematology and Medical Oncology, University Medical Centre Göttingen
- DOI
- https://doi.org/10.1038/s41467-018-03803-x
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 14
Abstract
Metabolic rewiring of cancer cells can be driven by both extrinsic and intrinsic factors. Here the authors show that microenvironmental factors induce metabolic rewiring of B-cell lymphoma through activation of STAT3 and NF-ΚB resulting in upregulation of the aminotransferase GOT2 and glutamine addiction.
