Nature Communications (Jan 2021)

Oncogenic herpesvirus KSHV triggers hallmarks of alternative lengthening of telomeres

  • Timothy P. Lippert,
  • Paulina Marzec,
  • Aurora I. Idilli,
  • Grzegorz Sarek,
  • Aleksandra Vancevska,
  • Mark Bower,
  • Paul J. Farrell,
  • Päivi M. Ojala,
  • Niklas Feldhahn,
  • Simon J. Boulton

DOI
https://doi.org/10.1038/s41467-020-20819-4
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 11

Abstract

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~15% of cancers induce alternative lengthening of telomeres (ALT) to activate telomere maintenance. Here, the authors reveal that infection with Kaposi’s sarcoma herpesvirus (KSHV) induces acquisition of ALT-like features in previously non-ALT cell lines.