Permeability of the Composite Magnetic Microcapsules Triggered by a Non-Heating Low-Frequency Magnetic Field
Ivan A. Burmistrov,
Maxim M. Veselov,
Alexander V. Mikheev,
Tatiana N. Borodina,
Tatiana V. Bukreeva,
Michael A. Chuev,
Sergey S. Starchikov,
Igor S. Lyubutin,
Vladimir V. Artemov,
Dmitry N. Khmelenin,
Natalia L. Klyachko,
Daria B. Trushina
Affiliations
Ivan A. Burmistrov
Shubnikov Institute of Crystallography of Federal Scientific Research Centre ‘‘Crystallography and Photonics” of Russian Academy of Sciences, 119333 Moscow, Russia
Maxim M. Veselov
Department of Chemical Enzymology, Lomonosov Moscow State University, 119991 Moscow, Russia
Alexander V. Mikheev
Shubnikov Institute of Crystallography of Federal Scientific Research Centre ‘‘Crystallography and Photonics” of Russian Academy of Sciences, 119333 Moscow, Russia
Tatiana N. Borodina
Shubnikov Institute of Crystallography of Federal Scientific Research Centre ‘‘Crystallography and Photonics” of Russian Academy of Sciences, 119333 Moscow, Russia
Tatiana V. Bukreeva
Shubnikov Institute of Crystallography of Federal Scientific Research Centre ‘‘Crystallography and Photonics” of Russian Academy of Sciences, 119333 Moscow, Russia
Michael A. Chuev
Valiev Institute of Physics and Technology of RAS, 117218 Moscow, Russia
Sergey S. Starchikov
Shubnikov Institute of Crystallography of Federal Scientific Research Centre ‘‘Crystallography and Photonics” of Russian Academy of Sciences, 119333 Moscow, Russia
Igor S. Lyubutin
Shubnikov Institute of Crystallography of Federal Scientific Research Centre ‘‘Crystallography and Photonics” of Russian Academy of Sciences, 119333 Moscow, Russia
Vladimir V. Artemov
Shubnikov Institute of Crystallography of Federal Scientific Research Centre ‘‘Crystallography and Photonics” of Russian Academy of Sciences, 119333 Moscow, Russia
Dmitry N. Khmelenin
Shubnikov Institute of Crystallography of Federal Scientific Research Centre ‘‘Crystallography and Photonics” of Russian Academy of Sciences, 119333 Moscow, Russia
Natalia L. Klyachko
Department of Chemical Enzymology, Lomonosov Moscow State University, 119991 Moscow, Russia
Daria B. Trushina
Shubnikov Institute of Crystallography of Federal Scientific Research Centre ‘‘Crystallography and Photonics” of Russian Academy of Sciences, 119333 Moscow, Russia
Nanosystems for targeted delivery and remote-controlled release of therapeutic agents has become a top priority in pharmaceutical science and drug development in recent decades. Application of a low frequency magnetic field (LFMF) as an external stimulus opens up opportunities to trigger release of the encapsulated bioactive substances with high locality and penetration ability without heating of biological tissue in vivo. Therefore, the development of novel microencapsulated drug formulations sensitive to LFMF is of paramount importance. Here, we report the result of LFMF-triggered release of the fluorescently labeled dextran from polyelectrolyte microcapsules modified with magnetic iron oxide nanoparticles. Polyelectrolyte microcapsules were obtained by a method of sequential deposition of oppositely charged poly(allylamine hydrochloride) (PAH) and poly(sodium 4-styrenesulfonate) (PSS) on the surface of colloidal vaterite particles. The synthesized single domain maghemite nanoparticles integrated into the polymer multilayers serve as magneto-mechanical actuators. We report the first systematic study of the effect of magnetic field with different frequencies on the permeability of the microcapsules. The in situ measurements of the optical density curves upon the 100 mT LFMF treatment were carried out for a range of frequencies from 30 to 150 Hz. Such fields do not cause any considerable heating of the magnetic nanoparticles but promote their rotating-oscillating mechanical motion that produces mechanical forces and deformations of the adjacent materials. We observed the changes in release of the encapsulated TRITC-dextran molecules from the PAH/PSS microcapsules upon application of the 50 Hz alternating magnetic field. The obtained results open new horizons for the design of polymer systems for triggered drug release without dangerous heating and overheating of tissues.
