Nature Communications (Apr 2021)
SOD1 regulates ribosome biogenesis in KRAS mutant non-small cell lung cancer
- Xiaowen Wang,
- Hong Zhang,
- Russell Sapio,
- Jun Yang,
- Justin Wong,
- Xin Zhang,
- Jessie Y. Guo,
- Sharon Pine,
- Holly Van Remmen,
- Hong Li,
- Eileen White,
- Chen Liu,
- Megerditch Kiledjian,
- Dimitri G. Pestov,
- X. F. Steven Zheng
Affiliations
- Xiaowen Wang
- Rutgers Cancer Institute of New Jersey, Rutgers, The State University of New Jersey
- Hong Zhang
- Rutgers Cancer Institute of New Jersey, Rutgers, The State University of New Jersey
- Russell Sapio
- Department of Cell Biology and Neuroscience, School of Osteopathic Medicine, Rowan University
- Jun Yang
- Department of Cell Biology and Neuroscience, Rutgers, The State University of New Jersey
- Justin Wong
- Rutgers Cancer Institute of New Jersey, Rutgers, The State University of New Jersey
- Xin Zhang
- Rutgers Cancer Institute of New Jersey, Rutgers, The State University of New Jersey
- Jessie Y. Guo
- Rutgers Cancer Institute of New Jersey, Rutgers, The State University of New Jersey
- Sharon Pine
- Rutgers Cancer Institute of New Jersey, Rutgers, The State University of New Jersey
- Holly Van Remmen
- Aging and Metabolism Program, Oklahoma Medical Research Foundation
- Hong Li
- Rutgers Cancer Institute of New Jersey, Rutgers, The State University of New Jersey
- Eileen White
- Rutgers Cancer Institute of New Jersey, Rutgers, The State University of New Jersey
- Chen Liu
- Rutgers Cancer Institute of New Jersey, Rutgers, The State University of New Jersey
- Megerditch Kiledjian
- Rutgers Cancer Institute of New Jersey, Rutgers, The State University of New Jersey
- Dimitri G. Pestov
- Department of Cell Biology and Neuroscience, School of Osteopathic Medicine, Rowan University
- X. F. Steven Zheng
- Rutgers Cancer Institute of New Jersey, Rutgers, The State University of New Jersey
- DOI
- https://doi.org/10.1038/s41467-021-22480-x
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 15
Abstract
The superoxide dismutase SOD1 is highly expressed in lung cancer but its role has not fully investigated yet. In this study, the authors demonstrate that SOD1 regulates ribosome biogenesis driving KRAS-driven lung tumorigenesis.
