Frontiers in Physics (Apr 2022)
Polymer-Gel Radiation Dosimetry of Laser-Based Relativistic Electron Sources for Biomedical Applications: First Qualitative Results and Experimental Challenges
- Ioannis Fitilis,
- Ioannis Fitilis,
- Anastasios Grigoriadis,
- Anastasios Grigoriadis,
- Ioannis Tazes,
- Ioannis Tazes,
- Stelios Petrakis,
- Stelios Petrakis,
- Georgia Andrianaki,
- Georgia Andrianaki,
- Vasilios Dimitriou,
- Vasilios Dimitriou,
- Efthimios Bakarezos,
- Efthimios Bakarezos,
- Emmanouil P. Benis,
- Emmanouil P. Benis,
- Irini Tsiapa,
- Themistoklis Boursianis,
- Georgios Kalaitzakis,
- Georgios Bontzos,
- Georgios Bontzos,
- Dimitrios A. Liakopoulos,
- Dimitrios A. Liakopoulos,
- Evangelos Pappas,
- Efstathios T. Detorakis,
- Efstathios T. Detorakis,
- Eugene L. Clark,
- Thomas G. Maris,
- Nektarios A. Papadogiannis,
- Nektarios A. Papadogiannis,
- Michael Tatarakis,
- Michael Tatarakis
Affiliations
- Ioannis Fitilis
- Institute of Plasma Physics and Lasers, Hellenic Mediterranean University Research Centre, Rethymno, Greece
- Ioannis Fitilis
- Department of Electronic Engineering, Hellenic Mediterranean University, Chania, Greece
- Anastasios Grigoriadis
- Institute of Plasma Physics and Lasers, Hellenic Mediterranean University Research Centre, Rethymno, Greece
- Anastasios Grigoriadis
- Department of Physics, University of Ioannina, Ioannina, Greece
- Ioannis Tazes
- Institute of Plasma Physics and Lasers, Hellenic Mediterranean University Research Centre, Rethymno, Greece
- Ioannis Tazes
- Department of Electronic Engineering, Hellenic Mediterranean University, Chania, Greece
- Stelios Petrakis
- Institute of Plasma Physics and Lasers, Hellenic Mediterranean University Research Centre, Rethymno, Greece
- Stelios Petrakis
- Department of Physics, University of Ioannina, Ioannina, Greece
- Georgia Andrianaki
- Institute of Plasma Physics and Lasers, Hellenic Mediterranean University Research Centre, Rethymno, Greece
- Georgia Andrianaki
- School of Production Engineering and Management, Technical University of Crete, Chania, Greece
- Vasilios Dimitriou
- Institute of Plasma Physics and Lasers, Hellenic Mediterranean University Research Centre, Rethymno, Greece
- Vasilios Dimitriou
- Department of Music Technology and Acoustics, Hellenic Mediterranean University, Rethymno, Greece
- Efthimios Bakarezos
- Institute of Plasma Physics and Lasers, Hellenic Mediterranean University Research Centre, Rethymno, Greece
- Efthimios Bakarezos
- Department of Music Technology and Acoustics, Hellenic Mediterranean University, Rethymno, Greece
- Emmanouil P. Benis
- Institute of Plasma Physics and Lasers, Hellenic Mediterranean University Research Centre, Rethymno, Greece
- Emmanouil P. Benis
- Department of Physics, University of Ioannina, Ioannina, Greece
- Irini Tsiapa
- Department of Medical Physics, School of Medicine, University of Crete, Heraklion, Greece
- Themistoklis Boursianis
- Department of Medical Physics, School of Medicine, University of Crete, Heraklion, Greece
- Georgios Kalaitzakis
- Department of Medical Physics, School of Medicine, University of Crete, Heraklion, Greece
- Georgios Bontzos
- Department of Ophthalmology, University Hospital of Heraklion, Heraklion, Greece
- Georgios Bontzos
- School of Medicine, University of Crete, Heraklion, Greece
- Dimitrios A. Liakopoulos
- Department of Ophthalmology, University Hospital of Heraklion, Heraklion, Greece
- Dimitrios A. Liakopoulos
- School of Medicine, University of Crete, Heraklion, Greece
- Evangelos Pappas
- Department of Biomedical Sciences, Radiology and Radiotherapy Sector, University of West Attica, Athens, Greece
- Efstathios T. Detorakis
- Department of Ophthalmology, University Hospital of Heraklion, Heraklion, Greece
- Efstathios T. Detorakis
- School of Medicine, University of Crete, Heraklion, Greece
- Eugene L. Clark
- Institute of Plasma Physics and Lasers, Hellenic Mediterranean University Research Centre, Rethymno, Greece
- Thomas G. Maris
- Department of Medical Physics, School of Medicine, University of Crete, Heraklion, Greece
- Nektarios A. Papadogiannis
- Institute of Plasma Physics and Lasers, Hellenic Mediterranean University Research Centre, Rethymno, Greece
- Nektarios A. Papadogiannis
- Department of Music Technology and Acoustics, Hellenic Mediterranean University, Rethymno, Greece
- Michael Tatarakis
- Institute of Plasma Physics and Lasers, Hellenic Mediterranean University Research Centre, Rethymno, Greece
- Michael Tatarakis
- Department of Electronic Engineering, Hellenic Mediterranean University, Chania, Greece
- DOI
- https://doi.org/10.3389/fphy.2022.727511
- Journal volume & issue
-
Vol. 10
Abstract
The generation of laser based relativistic electron sources involves impressive basic science as well as innovative applications. This study reports first novel qualitative results on polymer-gel radiation dosimetry of ultrafast laser-based relativistic electron beams. The fabricated polymer-gels are irradiated by the ultra-high dose rate (FLASH) laser-generated electron beams and then are analysed using magnetic resonance imaging. The reading of the irradiated dosimeters is performed using a clinical 1.5 T Magnetic Resonance Imaging system. Three-dimensional colour parametric T2 maps are then constructed from the original PD-T2 weighted images obtained from the clinical MRI scanner. For comparison, the gels are also irradiated with standard electron beams of various energies utilizing a radiotherapy clinical linear accelerator system. For the calibration measurements of the gel dosimetry method, special calibrated dosimetric films are also implemented. The preliminary results demonstrate the potential of polymer gel dosimetry for 3D-dose-distribution of FLASH type irradiation of laser generated electron beams. Furthermore, they illustrate potential issues related to the polymer gel based dosimetry in challenging irradiation arrangements, such as the oxygen sensitivity and necessity for oxygen impermeable container material.
Keywords
