Afferent specific role of NMDA receptors for the circuit integration of hippocampal neurogliaform cells

R. Chittajallu; J. C. Wester; M. T. Craig; E. Barksdale; X. Q. Yuan; G. Akgül; C. Fang; D. Collins; S. Hunt; K. A. Pelkey; C. J. McBain

doi:10.1038/s41467-017-00218-y

Nature Communications (Jul 2017)

Afferent specific role of NMDA receptors for the circuit integration of hippocampal neurogliaform cells

R. Chittajallu,
J. C. Wester,
M. T. Craig,
E. Barksdale,
X. Q. Yuan,
G. Akgül,
C. Fang,
D. Collins,
S. Hunt,
K. A. Pelkey,
C. J. McBain

Affiliations

R. Chittajallu: Section on Cellular and Synaptic Physiology, Eunice Kennedy–Shriver National Institute of Child Health and Human Development, National Institutes of Health
J. C. Wester: Section on Cellular and Synaptic Physiology, Eunice Kennedy–Shriver National Institute of Child Health and Human Development, National Institutes of Health
M. T. Craig: Section on Cellular and Synaptic Physiology, Eunice Kennedy–Shriver National Institute of Child Health and Human Development, National Institutes of Health
E. Barksdale: Section on Cellular and Synaptic Physiology, Eunice Kennedy–Shriver National Institute of Child Health and Human Development, National Institutes of Health
X. Q. Yuan: Section on Cellular and Synaptic Physiology, Eunice Kennedy–Shriver National Institute of Child Health and Human Development, National Institutes of Health
G. Akgül: Section on Cellular and Synaptic Physiology, Eunice Kennedy–Shriver National Institute of Child Health and Human Development, National Institutes of Health
C. Fang: Section on Cellular and Synaptic Physiology, Eunice Kennedy–Shriver National Institute of Child Health and Human Development, National Institutes of Health
D. Collins: Section on Cellular and Synaptic Physiology, Eunice Kennedy–Shriver National Institute of Child Health and Human Development, National Institutes of Health
S. Hunt: Section on Cellular and Synaptic Physiology, Eunice Kennedy–Shriver National Institute of Child Health and Human Development, National Institutes of Health
K. A. Pelkey: Section on Cellular and Synaptic Physiology, Eunice Kennedy–Shriver National Institute of Child Health and Human Development, National Institutes of Health
C. J. McBain: Section on Cellular and Synaptic Physiology, Eunice Kennedy–Shriver National Institute of Child Health and Human Development, National Institutes of Health

DOI: https://doi.org/10.1038/s41467-017-00218-y
Journal volume & issue: Vol. 8, no. 1
pp. 1 – 13

Abstract

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Proper brain function depends on the correct assembly of excitatory and inhibitory neurons into neural circuits. Here the authors show that during early postnatal development in mice, NMDAR signaling via activity of long-range synaptic inputs onto neurogliaform cells is required for their appropriate integration into the hippocampal circuitry.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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