Nature Communications (May 2019)
ZFYVE21 is a complement-induced Rab5 effector that activates non-canonical NF-κB via phosphoinosotide remodeling of endosomes
- Caodi Fang,
- Thomas D. Manes,
- Lufang Liu,
- Kevin Liu,
- Lingfeng Qin,
- Guangxin Li,
- Zuzana Tobiasova,
- Nancy C. Kirkiles-Smith,
- Manal Patel,
- Jonathan Merola,
- Whitney Fu,
- Rebecca Liu,
- Catherine Xie,
- Gregory T. Tietjen,
- Peter A. Nigrovic,
- George Tellides,
- Jordan S. Pober,
- Dan Jane-wit
Affiliations
- Caodi Fang
- Division of Cardiovascular Medicine, Yale University School of Medicine
- Thomas D. Manes
- Department of Immunobiology, Yale University School of Medicine
- Lufang Liu
- Division of Cardiovascular Medicine, Yale University School of Medicine
- Kevin Liu
- Division of Cardiovascular Medicine, Yale University School of Medicine
- Lingfeng Qin
- Department of Surgery, Yale University School of Medicine
- Guangxin Li
- Department of Surgery, Yale University School of Medicine
- Zuzana Tobiasova
- Department of Immunobiology, Yale University School of Medicine
- Nancy C. Kirkiles-Smith
- Department of Immunobiology, Yale University School of Medicine
- Manal Patel
- St. John’s College, University of Cambridge
- Jonathan Merola
- Department of Surgery, Yale University School of Medicine
- Whitney Fu
- Division of Cardiovascular Medicine, Yale University School of Medicine
- Rebecca Liu
- Department of Immunobiology, Yale University School of Medicine
- Catherine Xie
- Department of Immunobiology, Yale University School of Medicine
- Gregory T. Tietjen
- Department of Surgery, Yale University School of Medicine
- Peter A. Nigrovic
- Division of Rheumatology, Immunology and Allergy, Brigham and Women’s Hospital and Division of Immunology, Boston Children’s Hospital
- George Tellides
- Department of Surgery, Yale University School of Medicine
- Jordan S. Pober
- Department of Immunobiology, Yale University School of Medicine
- Dan Jane-wit
- Division of Cardiovascular Medicine, Yale University School of Medicine
- DOI
- https://doi.org/10.1038/s41467-019-10041-2
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 14
Abstract
Complement activation contributes to vascular inflammation in the contexts of allograft rejection and connective tissue disease. Here Fang et al. identify ZFYVE21 as a novel effector of Rab5 and find it regulates pro-inflammatory NF-κB signaling in endothelial cells in response to complement activation.
