SAGE Open Medical Case Reports (Aug 2020)

Multifocal cocaine-induced pyoderma gangrenosum: A report of two cases and review of literature

  • Alexandre Lemieux,
  • Zhuo Ran Cai,
  • Annie Belisle,
  • Suzanne Chartier,
  • Chantal Bolduc

DOI
https://doi.org/10.1177/2050313X20935736
Journal volume & issue
Vol. 8

Abstract

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Pyoderma gangrenosum is often associated with a systemic disease. Cocaine-induced pyoderma gangrenosum, most probably caused by levamisole, has been described recently and typically presents as multiple, large cribriform ulcers. Peri-nuclear antineutrophil cytoplasmic antibody is the most common serological finding. A strong counseling for cocaine cessation, combined with wound care and immunosuppressive therapy, is the mainstay of treatment. We present two cases of cocaine-induced pyoderma gangrenosum and correlate their findings with the typical clinical, histological and serological presentation.