Dynamic mRNA degradome analyses indicate a role of histone H3K4 trimethylation in association with meiosis-coupled mRNA decay in oocyte aging

Yun-Wen Wu; Sen Li; Wei Zheng; Yan-Chu Li; Lu Chen; Yong Zhou; Zuo-Qi Deng; Ge Lin; Heng-Yu Fan; Qian-Qian Sha

doi:10.1038/s41467-022-30928-x

Nature Communications (Jun 2022)

Dynamic mRNA degradome analyses indicate a role of histone H3K4 trimethylation in association with meiosis-coupled mRNA decay in oocyte aging

Yun-Wen Wu,
Sen Li,
Wei Zheng,
Yan-Chu Li,
Lu Chen,
Yong Zhou,
Zuo-Qi Deng,
Ge Lin,
Heng-Yu Fan,
Qian-Qian Sha

Affiliations

Yun-Wen Wu: MOE Key Laboratory for Biosystems Homeostasis & Protection and Innovation Center for Cell Signaling Network, Life Sciences Institute, Zhejiang University
Sen Li: Fertility Preservation Laboratory, Reproductive Medicine Center, Guangdong Second Provincial General Hospital
Wei Zheng: Research Center for Reproduction and Genetics in Hunan Province, Reproductive and Genetic Hospital of CITIC-XIANGYA
Yan-Chu Li: MOE Key Laboratory for Biosystems Homeostasis & Protection and Innovation Center for Cell Signaling Network, Life Sciences Institute, Zhejiang University
Lu Chen: Fertility Preservation Laboratory, Reproductive Medicine Center, Guangdong Second Provincial General Hospital
Yong Zhou: MOE Key Laboratory for Biosystems Homeostasis & Protection and Innovation Center for Cell Signaling Network, Life Sciences Institute, Zhejiang University
Zuo-Qi Deng: Fertility Preservation Laboratory, Reproductive Medicine Center, Guangdong Second Provincial General Hospital
Ge Lin: Research Center for Reproduction and Genetics in Hunan Province, Reproductive and Genetic Hospital of CITIC-XIANGYA
Heng-Yu Fan: Fertility Preservation Laboratory, Reproductive Medicine Center, Guangdong Second Provincial General Hospital
Qian-Qian Sha: MOE Key Laboratory for Biosystems Homeostasis & Protection and Innovation Center for Cell Signaling Network, Life Sciences Institute, Zhejiang University

DOI: https://doi.org/10.1038/s41467-022-30928-x
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 17

Abstract

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Developmental potential of oocytes decreases in women of advanced age. Here the authors observe impaired meiosis-coupled mRNA decay and reduced CXXC1-maintained histone H3K4 trimethylation in old oocytes of mouse and humans.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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