Nature Communications (Jun 2021)

BRCA1 binds TERRA RNA and suppresses R-Loop-based telomeric DNA damage

  • Jekaterina Vohhodina,
  • Liana J. Goehring,
  • Ben Liu,
  • Qing Kong,
  • Vladimir V. Botchkarev Jr.,
  • Mai Huynh,
  • Zhiqi Liu,
  • Fieda O. Abderazzaq,
  • Allison P. Clark,
  • Scott B. Ficarro,
  • Jarrod A. Marto,
  • Elodie Hatchi,
  • David M. Livingston

DOI
https://doi.org/10.1038/s41467-021-23716-6
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 16

Abstract

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BRCA1-mediated resolution of R-loops has previously been described. Here the authors reveal a functional association of BRCA1 with TERRA RNA at telomeres, which develops in an R-loop-, and a cell cycle-dependent manner.