Nature Communications (May 2020)

Systemic short chain fatty acids limit antitumor effect of CTLA-4 blockade in hosts with cancer

  • Clélia Coutzac,
  • Jean-Mehdi Jouniaux,
  • Angelo Paci,
  • Julien Schmidt,
  • Domenico Mallardo,
  • Atmane Seck,
  • Vahe Asvatourian,
  • Lydie Cassard,
  • Patrick Saulnier,
  • Ludovic Lacroix,
  • Paul-Louis Woerther,
  • Aurore Vozy,
  • Marie Naigeon,
  • Laetitia Nebot-Bral,
  • Mélanie Desbois,
  • Ester Simeone,
  • Christine Mateus,
  • Lisa Boselli,
  • Jonathan Grivel,
  • Emilie Soularue,
  • Patricia Lepage,
  • Franck Carbonnel,
  • Paolo Antonio Ascierto,
  • Caroline Robert,
  • Nathalie Chaput

DOI
https://doi.org/10.1038/s41467-020-16079-x
Journal volume & issue
Vol. 11, no. 1
pp. 1 – 13

Abstract

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The gut microbiota has been reported to regulate the efficacy of cancer therapy. Here, the authors show that short-chain fatty acids, which are generated through bacterial fermentation, increases immune tolerance leading to resistance to anti-CTLA-4 immunotherapy in mice and patients with metastatic melanoma.