Redox Status, Dose and Antioxidant Intake in Healthcare Workers Occupationally Exposed to Ionizing Radiation
Natividad Sebastià,
Lorena Olivares-González,
Alegría Montoro,
Joan-Francesc Barquinero,
Antonio José Canyada-Martinez,
David Hervás,
Pilar Gras,
Juan Ignacio Villaescusa,
Luis Martí-Bonmatí,
Bianca Tabita Muresan,
José Miguel Soriano,
Juan Manuel Campayo,
Joaquin Andani,
Oscar Alonso,
Regina Rodrigo
Affiliations
Natividad Sebastià
Service of Radiological Protection, Clinical Area of Medical Image, Avda. Fernando Abril Martorell, 106, Hospital U. P. La Fe, 46026 Valencia, Spain
Lorena Olivares-González
Pathophysiology and Therapies for Visual Disorders, Eduardo Primo Yúfera, 3, Research Center Príncipe Felipe (CIPF), 46012 Valencia, Spain
Alegría Montoro
Service of Radiological Protection, Clinical Area of Medical Image, Avda. Fernando Abril Martorell, 106, Hospital U. P. La Fe, 46026 Valencia, Spain
Joan-Francesc Barquinero
Biological Anthropology Unit Animal Biology, Plant Biology and Ecology Department, Universitat Autònoma de Barcelona (UAB), 08193 Bellaterra, Spain
Antonio José Canyada-Martinez
Biostatistics Unit, Avda. Fernando Abril Martorell, 106, Health Research Institute Hospital La Fe (IISLaFe), 46026 Valencia, Spain
David Hervás
Biostatistics Unit, Avda. Fernando Abril Martorell, 106, Health Research Institute Hospital La Fe (IISLaFe), 46026 Valencia, Spain
Pilar Gras
Service of Radiological Protection, Clinical Area of Medical Image, Avda. Fernando Abril Martorell, 106, Hospital U. P. La Fe, 46026 Valencia, Spain
Juan Ignacio Villaescusa
Service of Radiological Protection, Clinical Area of Medical Image, Avda. Fernando Abril Martorell, 106, Hospital U. P. La Fe, 46026 Valencia, Spain
Luis Martí-Bonmatí
Biomedical Imaging Research Group GIBI230, Avda. Fernando Abril Martorell, 106, Health Research Institute Hospital La Fe (IISLaFe), 46026 Valencia, Spain
Bianca Tabita Muresan
Service of Radiological Protection, Clinical Area of Medical Image, Avda. Fernando Abril Martorell, 106, Hospital U. P. La Fe, 46026 Valencia, Spain
José Miguel Soriano
Food & Health Lab, Institute of Materials Science, Parc Científic, Catedrático Agustín Escardino, Paterna (Valencia), University of Valencia, 46980 Valencia, Spain
Juan Manuel Campayo
Service of Radiological Protection, Clinical Area of Medical Image, Avda. Fernando Abril Martorell, 106, Hospital U. P. La Fe, 46026 Valencia, Spain
Joaquin Andani
Service of Occupational Risk Prevention, Avda. Fernando Abril Martorell, 106, Hospital U. P. La Fe, 46026 Valencia, Spain
Oscar Alonso
Service of Radiological Protection, Clinical Area of Medical Image, Avda. Fernando Abril Martorell, 106, Hospital U. P. La Fe, 46026 Valencia, Spain
Regina Rodrigo
Pathophysiology and Therapies for Visual Disorders, Eduardo Primo Yúfera, 3, Research Center Príncipe Felipe (CIPF), 46012 Valencia, Spain
The purpose of this study was to evaluate the relationship between blood redox status, dose and antioxidant dietary intake of different hospital staff groups exposed to low doses of ionizing radiation (LDIR) (Interventional Radiology and Cardiology, Radiation Oncology, and Nuclear Medicine) and non-exposed. Personal dose equivalent (from last year and cumulative), plasma antioxidant markers (total antioxidant capacity, extracellular superoxide dismutase activity, and glutathione/oxidized glutathione ratio), oxidative stress markers (nitrites and nitrates, and lipid peroxidation) and dietary intake (antioxidant capacity using ORAC values) were collected and analyzed from 28 non-exposed healthcare workers and 42 healthcare workers exposed to LDIR. Hospital staff exposed to LDIR presented a redox imbalance in blood that seems to correlate with dose. Workers from the Nuclear Medicine Unit were the most affected group with the lowest value of plasma antioxidant response and the highest value of plasma thiobarbituric acid reactive substances, TBARS (indicator of lipid peroxidation) of all four groups. Cumulative personal dose equivalent positively correlated with nitrites and negatively correlated with total antioxidant capacity in blood. The diet of healthcare workers from Nuclear Medicine Unit had higher ORAC values than the diet of non-exposed. Therefore, occupational exposure to LDIR, especially for the Nuclear Medicine Unit, seems to produce an imbalanced redox status in blood that would correlate with cumulative personal dose equivalent.
