Кардиоваскулярная терапия и профилактика (Dec 2007)

Tumor necrosis factor alpha gene polymorphism in patients wiht essential hypertension

  • Y. R. Timasheva,
  • T. R. Nasibullin,
  • A. N. Zakirova,
  • O. E. Mustafina

Journal volume & issue
Vol. 6, no. 6
pp. 5 – 9

Abstract

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Aim. To analyze the association between tumor necrosis factor-alpha gene –308 G/A polymorphism and essential arterial hypertension (EAH). Material and methods. The study included 354 EAH patients and 295 age-matched healthy subjects. DNA was extracted from venous blood. Genotyping was performed using polymerase chain reaction followed by restriction amplicon analysis. Results. TNFA -308*G/*G genotype frequency was significantly lower among EAH patients with stroke than in control group (60,98% vs 78,98%; p=0,015). EAH patients with TNFA -308 *G/*G genotype had lower stroke risk (OR=0,38; 95% CI: 0,21-0,83). Conclusion. The results obtained suggest that TNFA gene -308G/A polymorphism is involved in stroke pathogenesis among EAH patients.

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