Nature Communications (Mar 2019)
Complex formation of APP with GABAB receptors links axonal trafficking to amyloidogenic processing
- Margarita C. Dinamarca,
- Adi Raveh,
- Andy Schneider,
- Thorsten Fritzius,
- Simon Früh,
- Pascal D. Rem,
- Michal Stawarski,
- Txomin Lalanne,
- Rostislav Turecek,
- Myeongjeong Choo,
- Valérie Besseyrias,
- Wolfgang Bildl,
- Detlef Bentrop,
- Matthias Staufenbiel,
- Martin Gassmann,
- Bernd Fakler,
- Jochen Schwenk,
- Bernhard Bettler
Affiliations
- Margarita C. Dinamarca
- Department of Biomedicine, Institute of Physiology, University of Basel
- Adi Raveh
- Department of Biomedicine, Institute of Physiology, University of Basel
- Andy Schneider
- Faculty of Medicine, Institute of Physiology, University of Freiburg
- Thorsten Fritzius
- Department of Biomedicine, Institute of Physiology, University of Basel
- Simon Früh
- Department of Biomedicine, Institute of Physiology, University of Basel
- Pascal D. Rem
- Department of Biomedicine, Institute of Physiology, University of Basel
- Michal Stawarski
- Department of Biomedicine, Institute of Physiology, University of Basel
- Txomin Lalanne
- Department of Biomedicine, Institute of Physiology, University of Basel
- Rostislav Turecek
- Department of Biomedicine, Institute of Physiology, University of Basel
- Myeongjeong Choo
- Department of Biomedicine, Institute of Physiology, University of Basel
- Valérie Besseyrias
- Department of Biomedicine, Institute of Physiology, University of Basel
- Wolfgang Bildl
- Faculty of Medicine, Institute of Physiology, University of Freiburg
- Detlef Bentrop
- Faculty of Medicine, Institute of Physiology, University of Freiburg
- Matthias Staufenbiel
- Department of Cellular Neurology, Hertie Institute for Clinical Brain Research, University of Tübingen
- Martin Gassmann
- Department of Biomedicine, Institute of Physiology, University of Basel
- Bernd Fakler
- Faculty of Medicine, Institute of Physiology, University of Freiburg
- Jochen Schwenk
- Faculty of Medicine, Institute of Physiology, University of Freiburg
- Bernhard Bettler
- Department of Biomedicine, Institute of Physiology, University of Basel
- DOI
- https://doi.org/10.1038/s41467-019-09164-3
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 17
Abstract
The mechanisms that control the presynaptic abundance of GABAB receptors (GBRs) remains unclear. This study shows that sequence-related epitopes in APP, AJAP-1 and PIANP bind with nanomolar affinities to the N-terminal sushi-domain of presynaptic GBRs, and that selective loss of APP impaired GBR-mediated presynaptic inhibition and axonal GBR expression
