Receptor‐targeting nanomaterials alleviate binge drinking‐induced neurodegeneration as artificial neurotrophins
Jingyu Yang*,
Lirong Wang*,
Liwen Huang,
Xiaohang Che,
Zhen Zhang,
Chunxiao Wang,
Lihuan Bai,
Ping Liu,
Yanan Zhao,
Xiaomei Hu,
Bingyang Shi,
Yuequan Shen,
Xing‐Jie Liang,
Chunfu Wu,
Xue Xue
Affiliations
Jingyu Yang*
Department of Pharmacology Shenyang Pharmaceutical University Shenyang P. R. China
Lirong Wang*
CAS Key Laboratory of Standardization and Measurement for Nanotechnology National Center for Nanoscience and Technology of China Beijing P. R. China
Liwen Huang
State Key Laboratory of Medicinal Chemical Biology College of Pharmacy Nankai University Tianjin P. R. China
Xiaohang Che
Department of Pharmacology Shenyang Pharmaceutical University Shenyang P. R. China
Zhen Zhang
Department of Pharmacology Shenyang Pharmaceutical University Shenyang P. R. China
Chunxiao Wang
State Key Laboratory of Medicinal Chemical Biology College of Pharmacy Nankai University Tianjin P. R. China
Lihuan Bai
State Key Laboratory of Medicinal Chemical Biology College of Pharmacy Nankai University Tianjin P. R. China
Ping Liu
Department of Pharmacology Shenyang Pharmaceutical University Shenyang P. R. China
Yanan Zhao
Department of Pharmacology Shenyang Pharmaceutical University Shenyang P. R. China
Xiaomei Hu
Department of Pharmacology Shenyang Pharmaceutical University Shenyang P. R. China
Bingyang Shi
International Joint Center for Biomedical Innovation School of Life Sciences Henan University Kaifeng Henan P. R. China
Yuequan Shen
State Key Laboratory of Medicinal Chemical Biology College of Pharmacy Nankai University Tianjin P. R. China
Xing‐Jie Liang
CAS Center for Excellence in Nanoscience CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety National Center for Nanoscience and Technology of China Beijing P. R. China
Chunfu Wu
Department of Pharmacology Shenyang Pharmaceutical University Shenyang P. R. China
Xue Xue
State Key Laboratory of Medicinal Chemical Biology College of Pharmacy Nankai University Tianjin P. R. China
Abstract The distinguished properties of nanomaterials promote us to explore whether their intrinsic activities would be beneficial to disease treatment. Furthermore, understanding the molecular mechanism is thereby crucial for biomedical applications. Here, we investigate the therapeutic effects of single‐walled carbon nanotubes (SWNTs) in a rat model of binge alcohol‐induced neurodegeneration. With selection from four types of SWNT structures, bundled SWNTs (bSWNTs) facilitated the recovery of learning and memory via enhancing neuroprotection and neuroregeneration. We screened the potential target for bSWNTs, and found that bSWNTs have the abilities to directly interact with neurotrophic receptors, especially tropomyosin‐related kinase B (TrkB). Moreover, similar to the actions of endogenous neurotrophins, bSWNTs could trigger the dimerization and phosphorylation of TrkB, while these conformational changes resulted in activating their downstream signals involved in neuroprotection and neuroregeneration. With relatively clear mechanisms, these “artificial neurotrophins” provide a proof‐of‐concept example as an efficiently therapeutic strategy for the treatment of neurodegenerative diseases.