Signet cell rectal carcinoma with prostatic involvement detected by FAPI-04 PET-MRI fusion

Abstract

Abstract A 60-year-old male patient diagnosed with mucinous adenocarcinoma of lower third of rectum underwent abdominoperineal resection and permanent colostomy followed by adjuvant chemotherapy. Response evaluation with F-18 FDG PET-CT showed a complete metabolic response. After 6 months, CEA levels started increasing and clinically a recurrence was suspected. A restaging FDG PET-CT showed no obvious malignant disease. Patient presented again within a month with complaints of urinary retention and haematuria. CEA levels were further elevated, and Ga-68 FAPI-04 (FAPI) PET-CT was performed. FAPI PET-CT revealed prostatic and seminal vesicle disease involvement. Additionally, an MRI of pelvis was done and fused with FAPI PET for confirmation of prostatic involvement.

Keywords

• Signet cell adenocarcinoma
• FAPI
• Rectal adenocarcinoma
• Prostate secondaries
• FAPI MRI fusion
• Fibroblast activation protein inhibitor PET-CT