1403-A PTPN2/N1 inhibitor ABBV-CLS-484 unleashes potent anti-tumor immunity

• Wei Qiu,
• Qi Sun,
• Yi Yang,
• Chirag Patel,
• Meng Sun,
• Yue Liu,
• Kyle Halliwill,
• Sarah Kim,
• Rebecca Mathew,
• Jennifer M Frost,
• Jennifer A Roth,
• Domenick Kennedy,
• Robert T Manguso,
• Kathleen B Yates,
• Hakimeh Ebrahimi-Nik,
• Christina K Baumgartner,
• Arvin Iracheta-Vellve,
• Keith M Hamel,
• Kira Olander,
• Thomas GR Davis,
• Kathleen A McGuire,
• Geoff T Halvorsen,
• Omar I Avila,
• Ashwin V Kammula,
• Audrey J Muscato,
• Prasanthi Geda,
• Kelly Klinge,
• Zhaoming Xiong,
• Ryan Duggan,
• Liang Mu,
• Mitchell D Yeary,
• James C Patti,
• Tyler M Balon,
• Carey Backus,
• Angeline Chen,
• Kenton Longenecker,
• Joseph Klahn,
• Cara Hrusch,
• Navasona Krishnan,
• Charles W Hutchins,
• Jacqueline Aguado,
• Marinka Bulic,
• Payal Tiwari,
• Kayla J Colvin,
• Cun Lan Chuong,
• Ian C Kohnle,
• Matthew G Rees,
• Andrew Boghossian,
• Melissa Ronan,
• Meng-Ju Wu,
• Debattama R Sen,
• Gabriel K Griffin,
• Nabeel El-Bardeesy,
• Patricia Trusk,
• Joshua H Decker,
• Stacey Fossey,
• Marcia N Paddock,
• Elliot P Farney,
• Clay Beauregard,
• Philip R Kym

Affiliations

Wei Qiu

4AbbVie Inc., North Chicago, IL, USA

Qi Sun

1 Department of Nutrition, Harvard University T H Chan School of Public Health, Boston, Massachusetts, USA

Yi Yang

1Biocytogen Pharmaceuticals (Beijing) Co., Ltd., Beijing, China

Chirag Patel

7Calico Life Sciences, South San Francisco, CA, USA

Meng Sun

7Calico Life Sciences, South San Francisco, CA, USA

Yue Liu

7Calico Life Sciences, South San Francisco, CA, USA

Kyle Halliwill

8AbbVie, San Bruno, CA, USA

Sarah Kim

6Broad Institute of MIT and Harvard, Cambridge, MA, USA

Rebecca Mathew

10AbbVie Inc., South San Franscisco, CA, USA

Jennifer M Frost

4AbbVie Inc., North Chicago, IL, USA

Jennifer A Roth

6Broad Institute of MIT and Harvard, Cambridge, MA, USA

Domenick Kennedy

4AbbVie Inc., North Chicago, IL, USA

Robert T Manguso

3Center for Cancer Research, Massachusetts General Hospital, Boston, MA, USA

Kathleen B Yates

3Center for Cancer Research, Massachusetts General Hospital, Boston, MA, USA

Hakimeh Ebrahimi-Nik

3Center for Cancer Research, Massachusetts General Hospital, Boston, MA, USA

Christina K Baumgartner

4AbbVie Inc., North Chicago, IL, USA

Arvin Iracheta-Vellve

5AstraZeneca, Wellesley, MA, USA

Keith M Hamel

4AbbVie Inc., North Chicago, IL, USA

Kira Olander

6Broad Institute of MIT and Harvard, Cambridge, MA, USA

Thomas GR Davis

6Broad Institute of MIT and Harvard, Cambridge, MA, USA

Kathleen A McGuire

4AbbVie Inc., North Chicago, IL, USA

Geoff T Halvorsen

4AbbVie Inc., North Chicago, IL, USA

Omar I Avila

6Broad Institute of MIT and Harvard, Cambridge, MA, USA

Ashwin V Kammula

6Broad Institute of MIT and Harvard, Cambridge, MA, USA

Audrey J Muscato

6Broad Institute of MIT and Harvard, Cambridge, MA, USA

Prasanthi Geda

9Bristol Myers Squibb, Summit, NJ, USA

Kelly Klinge

4AbbVie Inc., North Chicago, IL, USA

Zhaoming Xiong

4AbbVie Inc., North Chicago, IL, USA

Ryan Duggan

4AbbVie Inc., North Chicago, IL, USA

Liang Mu

4AbbVie Inc., North Chicago, IL, USA

Mitchell D Yeary

6Broad Institute of MIT and Harvard, Cambridge, MA, USA

James C Patti

6Broad Institute of MIT and Harvard, Cambridge, MA, USA

Tyler M Balon

6Broad Institute of MIT and Harvard, Cambridge, MA, USA

Carey Backus

10AbbVie Inc., South San Franscisco, CA, USA

Angeline Chen

4AbbVie Inc., North Chicago, IL, USA

Kenton Longenecker

4AbbVie Inc., North Chicago, IL, USA

Joseph Klahn

11AbbVie, Elk Grove Village, IL, USA

Cara Hrusch

4AbbVie Inc., North Chicago, IL, USA

Navasona Krishnan

4AbbVie Inc., North Chicago, IL, USA

Charles W Hutchins

4AbbVie Inc., North Chicago, IL, USA

Jacqueline Aguado

4AbbVie Inc., North Chicago, IL, USA

Marinka Bulic

4AbbVie Inc., North Chicago, IL, USA

Payal Tiwari

6Broad Institute of MIT and Harvard, Cambridge, MA, USA

Kayla J Colvin

6Broad Institute of MIT and Harvard, Cambridge, MA, USA

Cun Lan Chuong

6Broad Institute of MIT and Harvard, Cambridge, MA, USA

Ian C Kohnle

6Broad Institute of MIT and Harvard, Cambridge, MA, USA

Matthew G Rees

6Broad Institute of MIT and Harvard, Cambridge, MA, USA

Andrew Boghossian

6Broad Institute of MIT and Harvard, Cambridge, MA, USA

Melissa Ronan

6Broad Institute of MIT and Harvard, Cambridge, MA, USA

Meng-Ju Wu

6Broad Institute of MIT and Harvard, Cambridge, MA, USA

Debattama R Sen

3Center for Cancer Research, Massachusetts General Hospital, Boston, MA, USA

Gabriel K Griffin

6Broad Institute of MIT and Harvard, Cambridge, MA, USA

Nabeel El-Bardeesy

3Center for Cancer Research, Massachusetts General Hospital, Boston, MA, USA

Patricia Trusk

4AbbVie Inc., North Chicago, IL, USA

Joshua H Decker

4AbbVie Inc., North Chicago, IL, USA

Stacey Fossey

4AbbVie Inc., North Chicago, IL, USA

Marcia N Paddock

7Calico Life Sciences, South San Francisco, CA, USA

Elliot P Farney

4AbbVie Inc., North Chicago, IL, USA

Clay Beauregard

7Calico Life Sciences, South San Francisco, CA, USA

Philip R Kym

4AbbVie Inc., North Chicago, IL, USA