Journal of Clinical and Experimental Investigations (2013-09-01)

The effects of typical and atypical antipsychotics on the electrical activity of the brain in a rat model

  • Oytun Erbaş,
  • Mustafa Yılmaz

Journal volume & issue
Vol. 4, no. 3
pp. 279 – 284


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Objective: Antipsychotic drugs are known to have strongeffect on the bioelectric activity in the brain. However,some studies addressing the changes on electroencephalography(EEG) caused by typical and atypical antipsychoticdrugs are conflicting. We aimed to compare the effectsof typical and atypical antipsychotics on the electricalactivity in the brain via EEG recordings in a rat model.Methods: Thirty-two Sprague Dawley adult male ratswere used in the study. The rats were divided into fivegroups, randomly (n=7, for each group). The first groupwas used as control group and administered 1 ml/kg salineintraperitoneally (IP). Haloperidol (1 mg/kg) (group 2),chlorpromazine (5 mg/kg) (group 3), olanzapine (1 mg/kg)(group 4), ziprasidone (1 mg/ kg) (group 5) were injectedIP for five consecutive days. Then, EEG recordings ofeach group were taken for 30 minutes.Results: The percentages of delta and theta waves inhaloperidol, chlorpromazine, olanzapine and ziprasidonegroups were found to have a highly significant differencecompared with the saline administration group (p<0.001).The theta waves in the olanzapine and ziprasidonegroups were increased compared with haloperidol andchlorpromazine groups (p<0.05).Conclusion: The typical and atypical antipsychotic drugsmay be risk factor for EEG abnormalities. This studyshows that antipsychotic drugs should be used with caution.J Clin Exp Invest 2013; 4 (3): 279-284Key words: Haloperidol, chlorpromazine, olanzapine,ziprasidone, EEG, rat