Molecules (Sep 2021)

A Simple Synthesis Route for Selectively Methylated <i>β</i>-Cyclodextrin Using a Copper Complex Sandwich Protecting Strategy

  • Stefan Bucur,
  • Marius Niculaua,
  • Catalina Ionica Ciobanu,
  • Neculai Catalin Lungu,
  • Ionel Mangalagiu

DOI
https://doi.org/10.3390/molecules26185669
Journal volume & issue
Vol. 26, no. 18
p. 5669

Abstract

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This communication reports a novel synthesis route for the preparation of monofunctionalized β-cyclodextrin in a single stage. The approach involves only the in-situ protection of secondary hydroxyl groups as an excellent alternative to the classical procedure involving a series of five steps of protection and deprotection of hydroxyl groups (both primary and secondary ones) belonging to β-cyclodextrin.

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