Sugar-mediated regulation of a c-di-GMP phosphodiesterase in Vibrio cholerae

Kyoo Heo; Young-Ha Park; Kyung-Ah Lee; Joonwon Kim; Hyeong-In Ham; Byung-Gee Kim; Won-Jae Lee; Yeong-Jae Seok

doi:10.1038/s41467-019-13353-5

Nature Communications (Nov 2019)

Sugar-mediated regulation of a c-di-GMP phosphodiesterase in Vibrio cholerae

Kyoo Heo,
Young-Ha Park,
Kyung-Ah Lee,
Joonwon Kim,
Hyeong-In Ham,
Byung-Gee Kim,
Won-Jae Lee,
Yeong-Jae Seok

Affiliations

Kyoo Heo: School of Biological Sciences and Institute of Microbiology, Seoul National University
Young-Ha Park: School of Biological Sciences and Institute of Microbiology, Seoul National University
Kyung-Ah Lee: School of Biological Sciences and National Creative Research Initiative Center for Hologenomics, Seoul National University
Joonwon Kim: School of Chemical and Biological Engineering and Institute of Molecular Biology and Genetics, Seoul National University
Hyeong-In Ham: School of Biological Sciences and Institute of Microbiology, Seoul National University
Byung-Gee Kim: School of Chemical and Biological Engineering and Institute of Molecular Biology and Genetics, Seoul National University
Won-Jae Lee: School of Biological Sciences and National Creative Research Initiative Center for Hologenomics, Seoul National University
Yeong-Jae Seok: School of Biological Sciences and Institute of Microbiology, Seoul National University

DOI: https://doi.org/10.1038/s41467-019-13353-5
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 10

Abstract

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Carbon sources can modulate biofilm formation and host colonization in Vibrio cholerae. Here, Heo et al. show that this process is mediated by a component of the PEP:carbohydrate phosphotransferase system (PTS), which regulates c-di-GMP hydrolysis by interacting with a c-di-GMP phosphodiesterase.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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