Nature Communications (Jan 2020)

Annexin-V stabilizes membrane defects by inducing lipid phase transition

  • Yi-Chih Lin,
  • Christophe Chipot,
  • Simon Scheuring

DOI
https://doi.org/10.1038/s41467-019-14045-w
Journal volume & issue
Vol. 11, no. 1
pp. 1 – 13

Abstract

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Annexins are cytoplasmic proteins, which bind to membranes exposing negatively charged phospholipids in a Ca2+-dependent manner. Here the authors use high-speed atomic force microscopy and other techniques to show that annexin-V self-assembles into highly structured lattices that lead to a membrane phase transition on PS-rich membranes.