Nature Communications (Nov 2020)
A circular RNA generated from an intron of the insulin gene controls insulin secretion
- Lisa Stoll,
- Adriana Rodríguez-Trejo,
- Claudiane Guay,
- Flora Brozzi,
- Mustafa Bilal Bayazit,
- Sonia Gattesco,
- Véronique Menoud,
- Jonathan Sobel,
- Ana Claudia Marques,
- Morten Trillingsgaard Venø,
- Jonathan Lou S. Esguerra,
- Mohammad Barghouth,
- Mara Suleiman,
- Lorella Marselli,
- Jørgen Kjems,
- Lena Eliasson,
- Erik Renström,
- Karim Bouzakri,
- Michel Pinget,
- Piero Marchetti,
- Romano Regazzi
Affiliations
- Lisa Stoll
- Department of Fundamental Neurosciences, University of Lausanne
- Adriana Rodríguez-Trejo
- Department of Fundamental Neurosciences, University of Lausanne
- Claudiane Guay
- Department of Fundamental Neurosciences, University of Lausanne
- Flora Brozzi
- Department of Fundamental Neurosciences, University of Lausanne
- Mustafa Bilal Bayazit
- Department of Fundamental Neurosciences, University of Lausanne
- Sonia Gattesco
- Department of Fundamental Neurosciences, University of Lausanne
- Véronique Menoud
- Department of Fundamental Neurosciences, University of Lausanne
- Jonathan Sobel
- Department of Fundamental Neurosciences, University of Lausanne
- Ana Claudia Marques
- Department of Computational Biology, University of Lausanne
- Morten Trillingsgaard Venø
- Interdisciplinary Nanoscience Center (iNANO) and Department of Molecular Biology and Genetics, Aarhus University
- Jonathan Lou S. Esguerra
- Islet Cell Exocytosis or Islet Pathophysiology Group, Lund University Diabetes Centre, Department of Clinical Sciences in Malmö, Lund University
- Mohammad Barghouth
- Islet Cell Exocytosis or Islet Pathophysiology Group, Lund University Diabetes Centre, Department of Clinical Sciences in Malmö, Lund University
- Mara Suleiman
- Department of Clinical and Experimental Medicine, University of Pisa
- Lorella Marselli
- Department of Clinical and Experimental Medicine, University of Pisa
- Jørgen Kjems
- Interdisciplinary Nanoscience Center (iNANO) and Department of Molecular Biology and Genetics, Aarhus University
- Lena Eliasson
- Islet Cell Exocytosis or Islet Pathophysiology Group, Lund University Diabetes Centre, Department of Clinical Sciences in Malmö, Lund University
- Erik Renström
- Islet Cell Exocytosis or Islet Pathophysiology Group, Lund University Diabetes Centre, Department of Clinical Sciences in Malmö, Lund University
- Karim Bouzakri
- UMR DIATHEC, EA 7294, Centre Européen d’Etude du Diabète, Université de Strasbourg, Fédération de Médecine Translationnelle de Strasbourg
- Michel Pinget
- UMR DIATHEC, EA 7294, Centre Européen d’Etude du Diabète, Université de Strasbourg, Fédération de Médecine Translationnelle de Strasbourg
- Piero Marchetti
- Department of Clinical and Experimental Medicine, University of Pisa
- Romano Regazzi
- Department of Fundamental Neurosciences, University of Lausanne
- DOI
- https://doi.org/10.1038/s41467-020-19381-w
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 13
Abstract
Circular RNAs contribute to the regulation of β-cell specific functions. Here the authors show that a circular RNA derived from one of the introns of the insulin gene is necessary for optimal insulin secretion from pancreatic islets and that its level is reduced in the islets of diabetic subjects.
