Nature Communications (Feb 2021)
Triptonide is a reversible non-hormonal male contraceptive agent in mice and non-human primates
- Zongliang Chang,
- Weibing Qin,
- Huili Zheng,
- Kathleen Schegg,
- Lu Han,
- Xiaohua Liu,
- Yue Wang,
- Zhuqing Wang,
- Hayden McSwiggin,
- Hongying Peng,
- Shuiqiao Yuan,
- Jiabao Wu,
- Yongxia Wang,
- Shenghui Zhu,
- Yanjia Jiang,
- Hua Nie,
- Yuan Tang,
- Yu Zhou,
- Michael J. M. Hitchcock,
- Yunge Tang,
- Wei Yan
Affiliations
- Zongliang Chang
- Department of Physiology and Cell Biology, University of Nevada, Reno School of Medicine
- Weibing Qin
- NHC Key Laboratory of Male Reproduction and Genetics
- Huili Zheng
- Department of Physiology and Cell Biology, University of Nevada, Reno School of Medicine
- Kathleen Schegg
- Department of Physiology and Cell Biology, University of Nevada, Reno School of Medicine
- Lu Han
- NHC Key Laboratory of Male Reproduction and Genetics
- Xiaohua Liu
- NHC Key Laboratory of Male Reproduction and Genetics
- Yue Wang
- Department of Physiology and Cell Biology, University of Nevada, Reno School of Medicine
- Zhuqing Wang
- Department of Physiology and Cell Biology, University of Nevada, Reno School of Medicine
- Hayden McSwiggin
- Department of Physiology and Cell Biology, University of Nevada, Reno School of Medicine
- Hongying Peng
- Department of Physiology and Cell Biology, University of Nevada, Reno School of Medicine
- Shuiqiao Yuan
- Department of Physiology and Cell Biology, University of Nevada, Reno School of Medicine
- Jiabao Wu
- NHC Key Laboratory of Male Reproduction and Genetics
- Yongxia Wang
- NHC Key Laboratory of Male Reproduction and Genetics
- Shenghui Zhu
- NHC Key Laboratory of Male Reproduction and Genetics
- Yanjia Jiang
- NHC Key Laboratory of Male Reproduction and Genetics
- Hua Nie
- NHC Key Laboratory of Male Reproduction and Genetics
- Yuan Tang
- NHC Key Laboratory of Male Reproduction and Genetics
- Yu Zhou
- NHC Key Laboratory of Male Reproduction and Genetics
- Michael J. M. Hitchcock
- Department of Microbiology and Immunology, University of Nevada, Reno School of Medicine
- Yunge Tang
- NHC Key Laboratory of Male Reproduction and Genetics
- Wei Yan
- Department of Physiology and Cell Biology, University of Nevada, Reno School of Medicine
- DOI
- https://doi.org/10.1038/s41467-021-21517-5
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 14
Abstract
No male contraceptive pills are currently available. Here, the authors use triptonide, a compound derived from a Chinese plant, to deform sperm so that they cannot move properly, thereby causing reversible infertility in male mice and monkeys.
