Frontiers in Genetics (Nov 2021)

A Web Tool for Consensus Gene Regulatory Network Construction

  • Chiranjib Sarkar,
  • Rajender Parsad,
  • Dwijesh C. Mishra,
  • Anil Rai

DOI
https://doi.org/10.3389/fgene.2021.745827
Journal volume & issue
Vol. 12

Abstract

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Gene regulatory network (GRN) construction involves various steps of complex computational steps. This step-by-step procedure requires prior knowledge of programming languages such as R. Development of a web tool may reduce this complexity in the analysis steps which can be easy accessible for the user. In this study, a web tool for constructing consensus GRN by combining the outcomes obtained from four methods, namely, correlation, principal component regression, partial least square, and ridge regression, has been developed. We have designed the web tool with an interactive and user-friendly web page using the php programming language. We have used R script for the analysis steps which run in the background of the user interface. Users can upload gene expression data for constructing consensus GRN. The output obtained from analysis will be available in downloadable form in the result window of the web tool.

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