Structures and stabilization of kinetoplastid-specific split rRNAs revealed by comparing leishmanial and human ribosomes

Xing Zhang; Mason Lai; Winston Chang; Iris Yu; Ke Ding; Jan Mrazek; Hwee L. Ng; Otto O. Yang; Dmitri A. Maslov; Z. Hong Zhou

doi:10.1038/ncomms13223

Nature Communications (Oct 2016)

Structures and stabilization of kinetoplastid-specific split rRNAs revealed by comparing leishmanial and human ribosomes

Xing Zhang,
Mason Lai,
Winston Chang,
Iris Yu,
Ke Ding,
Jan Mrazek,
Hwee L. Ng,
Otto O. Yang,
Dmitri A. Maslov,
Z. Hong Zhou

Affiliations

Xing Zhang: Center of Cryo Electron Microscopy, Zhejiang University School of Medicine
Mason Lai: Department of Microbiology, Immunology and Molecular Genetics, University of California
Winston Chang: Department of Microbiology, Immunology and Molecular Genetics, University of California
Iris Yu: Department of Microbiology, Immunology and Molecular Genetics, University of California
Ke Ding: Department of Microbiology, Immunology and Molecular Genetics, University of California
Jan Mrazek: Division of Infectious Diseases, Department of Medicine, David Geffen School of Medicine, University of California Los Angeles
Hwee L. Ng: Division of Infectious Diseases, Department of Medicine, David Geffen School of Medicine, University of California Los Angeles
Otto O. Yang: California NanoSystems Institute, University of California
Dmitri A. Maslov: Department of Biology, University of California
Z. Hong Zhou: California NanoSystems Institute, University of California

DOI: https://doi.org/10.1038/ncomms13223
Journal volume & issue: Vol. 7, no. 1
pp. 1 – 10

Abstract

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Leishmania donovani is a protozoan parasite that can cause fatal infections in humans. Here the authors present a high resolution cryoEM structure of the L. donovani80S ribosome and compare it to its human counterpart to provide insight into the basis for drug selectivity towards this eukaryotic parasite.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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