Nature Communications (Oct 2016)

Increased global transcription activity as a mechanism of replication stress in cancer

  • Panagiotis Kotsantis,
  • Lara Marques Silva,
  • Sarah Irmscher,
  • Rebecca M. Jones,
  • Lisa Folkes,
  • Natalia Gromak,
  • Eva Petermann

DOI
https://doi.org/10.1038/ncomms13087
Journal volume & issue
Vol. 7, no. 1
pp. 1 – 13

Abstract

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Cancer cells proliferate at high rates and incur replication stress. Here, the authors show that this can be the consequence of oncogene-induced higher transcriptional activity, which, through increased RNA synthesis and R-loop accumulation, results in replication fork slowing and DNA damage.