UTX is an escape from X-inactivation tumor-suppressor in B cell lymphoma

Xiaoxi Li; Yanli Zhang; Liting Zheng; Mingxian Liu; Charlie Degui Chen; Hai Jiang

doi:10.1038/s41467-018-05084-w

Nature Communications (Jul 2018)

UTX is an escape from X-inactivation tumor-suppressor in B cell lymphoma

Xiaoxi Li,
Yanli Zhang,
Liting Zheng,
Mingxian Liu,
Charlie Degui Chen,
Hai Jiang

Affiliations

Xiaoxi Li: State Key Laboratory of Cell Biology, Key Laboratory of Systems Biology, Innovation Center for Cell Signaling Network, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, University of Chinese Academy of Sciences
Yanli Zhang: State Key Laboratory of Cell Biology, Key Laboratory of Systems Biology, Innovation Center for Cell Signaling Network, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, University of Chinese Academy of Sciences
Liting Zheng: State Key Laboratory of Molecular Biology, Shanghai Key Laboratory of Molecular Andrology, Innovation Center for Cell Signaling Network, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, University of Chinese Academy of Sciences
Mingxian Liu: State Key Laboratory of Cell Biology, Key Laboratory of Systems Biology, Innovation Center for Cell Signaling Network, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, University of Chinese Academy of Sciences
Charlie Degui Chen: State Key Laboratory of Molecular Biology, Shanghai Key Laboratory of Molecular Andrology, Innovation Center for Cell Signaling Network, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, University of Chinese Academy of Sciences
Hai Jiang: State Key Laboratory of Cell Biology, Key Laboratory of Systems Biology, Innovation Center for Cell Signaling Network, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, University of Chinese Academy of Sciences

DOI: https://doi.org/10.1038/s41467-018-05084-w
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 10

Abstract

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UTX is a tumor suppressor gene located on the X-chromosome so it could potentially contribute to the cancer gender bias. Here the authors, using a mouse model of B cell lymphoma, show that UTX is a dosage sensitive tumor suppressor and may be responsible for some of the increased incidence and possibly aggressiveness of male cancers that harbour UTX mutations.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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