Nature Communications (Jun 2022)
Comprehensive genetic analysis of the human lipidome identifies loci associated with lipid homeostasis with links to coronary artery disease
- Gemma Cadby,
- Corey Giles,
- Phillip E. Melton,
- Kevin Huynh,
- Natalie A. Mellett,
- Thy Duong,
- Anh Nguyen,
- Michelle Cinel,
- Alex Smith,
- Gavriel Olshansky,
- Tingting Wang,
- Marta Brozynska,
- Mike Inouye,
- Nina S. McCarthy,
- Amir Ariff,
- Joseph Hung,
- Jennie Hui,
- John Beilby,
- Marie-Pierre Dubé,
- Gerald F. Watts,
- Sonia Shah,
- Naomi R. Wray,
- Wei Ling Florence Lim,
- Pratishtha Chatterjee,
- Ian Martins,
- Simon M. Laws,
- Tenielle Porter,
- Michael Vacher,
- Ashley I. Bush,
- Christopher C. Rowe,
- Victor L. Villemagne,
- David Ames,
- Colin L. Masters,
- Kevin Taddei,
- Matthias Arnold,
- Gabi Kastenmüller,
- Kwangsik Nho,
- Andrew J. Saykin,
- Xianlin Han,
- Rima Kaddurah-Daouk,
- Ralph N. Martins,
- John Blangero,
- Peter J. Meikle,
- Eric K. Moses
Affiliations
- Gemma Cadby
- School of Population and Global Health, University of Western Australia
- Corey Giles
- Baker Heart and Diabetes Institute
- Phillip E. Melton
- School of Population and Global Health, University of Western Australia
- Kevin Huynh
- Baker Heart and Diabetes Institute
- Natalie A. Mellett
- Baker Heart and Diabetes Institute
- Thy Duong
- Baker Heart and Diabetes Institute
- Anh Nguyen
- Baker Heart and Diabetes Institute
- Michelle Cinel
- Baker Heart and Diabetes Institute
- Alex Smith
- Baker Heart and Diabetes Institute
- Gavriel Olshansky
- Baker Heart and Diabetes Institute
- Tingting Wang
- Baker Heart and Diabetes Institute
- Marta Brozynska
- Baker Heart and Diabetes Institute
- Mike Inouye
- Baker Heart and Diabetes Institute
- Nina S. McCarthy
- School of Biomedical Sciences, University of Western Australia
- Amir Ariff
- School of Women’s and Children’s Health, University of New South Wales
- Joseph Hung
- School of Medicine, The University of Western Australia
- Jennie Hui
- Busselton Population Medical Research Institute Inc.
- John Beilby
- Busselton Population Medical Research Institute Inc.
- Marie-Pierre Dubé
- Université de Montréal Beaulieu-Saucier Pharmacogenomics Centre, Montreal Heart Institute
- Gerald F. Watts
- School of Medicine, The University of Western Australia
- Sonia Shah
- Institute for Molecular Biosciences, University of Queensland
- Naomi R. Wray
- Institute for Molecular Biosciences, University of Queensland
- Wei Ling Florence Lim
- School of Medical and Health Sciences, Edith Cowan University
- Pratishtha Chatterjee
- School of Medical and Health Sciences, Edith Cowan University
- Ian Martins
- School of Medical and Health Sciences, Edith Cowan University
- Simon M. Laws
- Centre for Precision Health, Edith Cowan University
- Tenielle Porter
- Centre for Precision Health, Edith Cowan University
- Michael Vacher
- Centre for Precision Health, Edith Cowan University
- Ashley I. Bush
- The Florey Department of Neuroscience and Mental Health, The University of Melbourne
- Christopher C. Rowe
- The Florey Department of Neuroscience and Mental Health, The University of Melbourne
- Victor L. Villemagne
- Department of Molecular Imaging and Therapy, Austin Health
- David Ames
- National Ageing Research Institute
- Colin L. Masters
- The Florey Department of Neuroscience and Mental Health, The University of Melbourne
- Kevin Taddei
- School of Medical and Health Sciences, Edith Cowan University
- Matthias Arnold
- Department of Psychiatry and Behavioral Sciences, Duke University
- Gabi Kastenmüller
- Institute of Computational Biology, Helmholtz Zentrum München, German Research Center for Environmental Health
- Kwangsik Nho
- Department of Radiology and Imaging Sciences, Indiana University School of Medicine
- Andrew J. Saykin
- Department of Radiology and Imaging Sciences, Indiana University School of Medicine
- Xianlin Han
- Barshop Institute for Longevity and Aging Studies, University of Texas Health Science Center at San Antonio
- Rima Kaddurah-Daouk
- Department of Psychiatry and Behavioral Sciences, Duke University
- Ralph N. Martins
- School of Medical and Health Sciences, Edith Cowan University
- John Blangero
- South Texas Diabetes and Obesity Institute, The University of Texas Rio Grande Valley
- Peter J. Meikle
- Baker Heart and Diabetes Institute
- Eric K. Moses
- Menzies Research Institute, University of Tasmania
- DOI
- https://doi.org/10.1038/s41467-022-30875-7
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 17
Abstract
Dysregulation of lipid metabolism is associated with coronary artery disease (CAD). Here, the authors perform GWAS of the serum lipidome to identify variants associated with lipid species that are putatively in the mechanistic pathway to CAD.
