Nature Communications (Jul 2022)

Actin nano-architecture of phagocytic podosomes

  • J. Cody Herron,
  • Shiqiong Hu,
  • Takashi Watanabe,
  • Ana T. Nogueira,
  • Bei Liu,
  • Megan E. Kern,
  • Jesse Aaron,
  • Aaron Taylor,
  • Michael Pablo,
  • Teng-Leong Chew,
  • Timothy C. Elston,
  • Klaus M. Hahn

DOI
https://doi.org/10.1038/s41467-022-32038-0
Journal volume & issue
Vol. 13, no. 1
pp. 1 – 16

Abstract

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Podosomes are actin structures important in multiple cell functions. Here, the authors use iPALM microscopy to reveal an “hourglass” shape of the podosome actin core, a protruding “knob” at the bottom of the core, and two actin networks extending from it.