Emergent properties as by-products of prebiotic evolution of aminoacylation ribozymes

Evan Janzen; Yuning Shen; Alberto Vázquez-Salazar; Ziwei Liu; Celia Blanco; Josh Kenchel; Irene A. Chen

doi:10.1038/s41467-022-31387-0

Nature Communications (Jun 2022)

Emergent properties as by-products of prebiotic evolution of aminoacylation ribozymes

Evan Janzen,
Yuning Shen,
Alberto Vázquez-Salazar,
Ziwei Liu,
Celia Blanco,
Josh Kenchel,
Irene A. Chen

Affiliations

Evan Janzen: Program in Biomolecular Science and Engineering, University of California
Yuning Shen: Department of Chemistry and Biochemistry, University of California
Alberto Vázquez-Salazar: Department of Chemical and Biomolecular Engineering, Department of Chemistry and Biochemistry, University of California
Ziwei Liu: MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge Biomedical Campus
Celia Blanco: Department of Chemical and Biomolecular Engineering, Department of Chemistry and Biochemistry, University of California
Josh Kenchel: Program in Biomolecular Science and Engineering, University of California
Irene A. Chen: Program in Biomolecular Science and Engineering, University of California

DOI: https://doi.org/10.1038/s41467-022-31387-0
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 12

Abstract

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Complex biochemical systems exhibit traits that appear to be highly adapted. Studies of catalytic RNA demonstrate that adaptive traits, such as increased specificity and error tolerance, could originate as evolutionary by-products.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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