Microbial recognition by GEF-H1 controls IKKε mediated activation of IRF5

Yun Zhao; Rachid Zagani; Sung-Moo Park; Naohiro Yoshida; Pankaj Shah; Hans-Christian Reinecker

doi:10.1038/s41467-019-09283-x

Nature Communications (Mar 2019)

Microbial recognition by GEF-H1 controls IKKε mediated activation of IRF5

Yun Zhao,
Rachid Zagani,
Sung-Moo Park,
Naohiro Yoshida,
Pankaj Shah,
Hans-Christian Reinecker

Affiliations

Yun Zhao: Department of Medicine, Gastrointestinal Unit and Center for the Study of Inflammatory Bowel Disease, Massachusetts General Hospital, Harvard Medical School
Rachid Zagani: Department of Medicine, Gastrointestinal Unit and Center for the Study of Inflammatory Bowel Disease, Massachusetts General Hospital, Harvard Medical School
Sung-Moo Park: Department of Medicine, Gastrointestinal Unit and Center for the Study of Inflammatory Bowel Disease, Massachusetts General Hospital, Harvard Medical School
Naohiro Yoshida: Department of Medicine, Gastrointestinal Unit and Center for the Study of Inflammatory Bowel Disease, Massachusetts General Hospital, Harvard Medical School
Pankaj Shah: Department of Medicine, Gastrointestinal Unit and Center for the Study of Inflammatory Bowel Disease, Massachusetts General Hospital, Harvard Medical School
Hans-Christian Reinecker: Department of Medicine, Gastrointestinal Unit and Center for the Study of Inflammatory Bowel Disease, Massachusetts General Hospital, Harvard Medical School

DOI: https://doi.org/10.1038/s41467-019-09283-x
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 13

Abstract

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The transcription factor IRF5 is essential for immune defense against pathogens. Here, the authors show that the microtubule-associated factor GEF-H1 plays a critical role in host defense against Listeria monocytogenes in macrophages via activation of the IRF5 kinase IKKε.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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