Zdorovʹe Rebenka (Mar 2013)

The Role of α-Defensins 1–3 in Antimicrobial Protection Forming in Children with Recurrent Bronchitis Caused by Bacteria of the Genus Haemophilus

  • G.O. Lezhenko,
  • O.Ye. Abaturov,
  • O.Ye. Pashkova,
  • L.I. Pantyushenko

DOI
https://doi.org/10.22141/2224-0551.2.45.2013.88021
Journal volume & issue
Vol. 8, no. 2.45
pp. 22 – 26

Abstract

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The level of α-defensins 1–3 (HNP 1–3) has been analyzed in the blood plasma of children with recurrent bronchitis caused by bacteria of the genus Haemophilus. It is shown that the level of HNP 1–3 in the blood plasma depends on the form of Haemophilus. Trigger of HNP 1–3 outflow for neutrophils was the presence of bacterial capsule while presence of L-forms of Haemophilus influenzae wasn’t associated with increase in synthesis of antimicrobial peptides that could be one of the factors of forming of Haemophilus antibiotic resistance.

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