Comparison between Oncotype DX test and standard prognostic criteria in estrogen receptor positive early-stage breast cancer

Abstract

Objective: To compare the prognosis estimated by standardprognostic criteria versus the prognosis estimated by the OncotypeDX. Methods: A retrospective study was performed on 22 patientswith positive estrogen receptor, early-stage breast cancer whohad an Oncotype DX recurrence score available. Results: Kappavalue between Oncotype DX and standard prognostic criteriawas: Adjuvant! (K = 0.091), Adjuvant! (Transbig) (K = 0.182) andNational Comprehensive Cancer Network (K = 0.091). The Fisher’sexact test did not show correlation between Oncotype and standardprognostic criteria. Conclusion: Standard prognostic criteria showedno correlation with Oncotype DX.

Keywords

• Breast neoplasms/diagnosis
• Gene expression profiling