A practical fluorosulfonylating platform via photocatalytic imidazolium-based SO2F radical reagent

Weigang Zhang; Heyin Li; Xiaojuan Li; Zhenlei Zou; Mengjun Huang; Jiyang Liu; Xiaochen Wang; Shengyang Ni; Yi Pan; Yi Wang

doi:10.1038/s41467-022-31296-2

Nature Communications (Jun 2022)

A practical fluorosulfonylating platform via photocatalytic imidazolium-based SO2F radical reagent

Weigang Zhang,
Heyin Li,
Xiaojuan Li,
Zhenlei Zou,
Mengjun Huang,
Jiyang Liu,
Xiaochen Wang,
Shengyang Ni,
Yi Pan,
Yi Wang

Affiliations

Weigang Zhang: State Key Laboratory of Coordination Chemistry, Jiangsu Key Laboratory of Advanced Organic Materials, School of Chemistry and Chemical Engineering, Nanjing University
Heyin Li: State Key Laboratory of Coordination Chemistry, Jiangsu Key Laboratory of Advanced Organic Materials, School of Chemistry and Chemical Engineering, Nanjing University
Xiaojuan Li: State Key Laboratory of Coordination Chemistry, Jiangsu Key Laboratory of Advanced Organic Materials, School of Chemistry and Chemical Engineering, Nanjing University
Zhenlei Zou: State Key Laboratory of Coordination Chemistry, Jiangsu Key Laboratory of Advanced Organic Materials, School of Chemistry and Chemical Engineering, Nanjing University
Mengjun Huang: State Key Laboratory of Coordination Chemistry, Jiangsu Key Laboratory of Advanced Organic Materials, School of Chemistry and Chemical Engineering, Nanjing University
Jiyang Liu: State Key Laboratory of Coordination Chemistry, Jiangsu Key Laboratory of Advanced Organic Materials, School of Chemistry and Chemical Engineering, Nanjing University
Xiaochen Wang: State Key Laboratory of Coordination Chemistry, Jiangsu Key Laboratory of Advanced Organic Materials, School of Chemistry and Chemical Engineering, Nanjing University
Shengyang Ni: State Key Laboratory of Coordination Chemistry, Jiangsu Key Laboratory of Advanced Organic Materials, School of Chemistry and Chemical Engineering, Nanjing University
Yi Pan: State Key Laboratory of Coordination Chemistry, Jiangsu Key Laboratory of Advanced Organic Materials, School of Chemistry and Chemical Engineering, Nanjing University
Yi Wang: State Key Laboratory of Coordination Chemistry, Jiangsu Key Laboratory of Advanced Organic Materials, School of Chemistry and Chemical Engineering, Nanjing University

DOI: https://doi.org/10.1038/s41467-022-31296-2
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 8

Abstract

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Sulfonyl fluorides have potential application in chemical biology, materials science, and drug discovery, but their preparation remains challenging. Here, the authors report an air-stable fluorosulfonylating reagent that enables the radical fluorosulfonylation, hydrofluorosulfonylation and migratory SO2F-difunctionalization of unsaturated hydrocarbons to construct a variety of sulfonyl fluoride compounds.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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