Covalent Inhibition of a Host–Pathogen Protein–Protein Interaction Reduces the Infectivity of Streptococcus pneumoniae

• Yuhan Lyu,
• Fan Yang,
• Bharathi Sundaresh,
• Federico Rosconi,
• Tim van Opijnen,
• Jianmin Gao

Affiliations

Yuhan Lyu

Department of Chemistry, Merkert Chemistry Center, Boston College, Chestnut Hill, Massachusetts, United States

Fan Yang

Department of Chemistry, Merkert Chemistry Center, Boston College, Chestnut Hill, Massachusetts, United States

Bharathi Sundaresh

Department of Biology, Boston College, Chestnut Hill, Massachusetts, United States

Federico Rosconi

Department of Biology, Boston College, Chestnut Hill, Massachusetts, United States

Tim van Opijnen

Broad Institute of Massachusetts Institute of Technology and Harvard University, Cambridge, Massachusetts, United States

Jianmin Gao

Department of Chemistry, Merkert Chemistry Center, Boston College, Chestnut Hill, Massachusetts, United States