Nature Communications (Nov 2022)
Analysis of clinically relevant variants from ancestrally diverse Asian genomes
- Sock Hoai Chan,
- Yasmin Bylstra,
- Jing Xian Teo,
- Jyn Ling Kuan,
- Nicolas Bertin,
- Mar Gonzalez-Porta,
- Maxime Hebrard,
- Roberto Tirado-Magallanes,
- Joanna Hui Juan Tan,
- Justin Jeyakani,
- Zhihui Li,
- Jin Fang Chai,
- Yap Seng Chong,
- Sonia Davila,
- Liuh Ling Goh,
- Eng Sing Lee,
- Eleanor Wong,
- Tien Yin Wong,
- SG10K_Health Consortium,
- Shyam Prabhakar,
- Jianjun Liu,
- Ching-Yu Cheng,
- Birgit Eisenhaber,
- Neerja Karnani,
- Khai Pang Leong,
- Xueling Sim,
- Khung Keong Yeo,
- John C. Chambers,
- E-Shyong Tai,
- Patrick Tan,
- Saumya S. Jamuar,
- Joanne Ngeow,
- Weng Khong Lim
Affiliations
- Sock Hoai Chan
- Cancer Genetics Service, Division of Medical Oncology, National Cancer Centre Singapore
- Yasmin Bylstra
- SingHealth Duke-NUS Institute of Precision Medicine
- Jing Xian Teo
- SingHealth Duke-NUS Institute of Precision Medicine
- Jyn Ling Kuan
- SingHealth Duke-NUS Institute of Precision Medicine
- Nicolas Bertin
- Genome Research Informatics & Data Science Platform, Genome Institute of Singapore, Agency for Science, Technology and Research
- Mar Gonzalez-Porta
- Genome Research Informatics & Data Science Platform, Genome Institute of Singapore, Agency for Science, Technology and Research
- Maxime Hebrard
- Genome Research Informatics & Data Science Platform, Genome Institute of Singapore, Agency for Science, Technology and Research
- Roberto Tirado-Magallanes
- Genome Research Informatics & Data Science Platform, Genome Institute of Singapore, Agency for Science, Technology and Research
- Joanna Hui Juan Tan
- Genome Research Informatics & Data Science Platform, Genome Institute of Singapore, Agency for Science, Technology and Research
- Justin Jeyakani
- Genome Research Informatics & Data Science Platform, Genome Institute of Singapore, Agency for Science, Technology and Research
- Zhihui Li
- Genome Research Informatics & Data Science Platform, Genome Institute of Singapore, Agency for Science, Technology and Research
- Jin Fang Chai
- Saw Swee Hock School of Public Health, National University of Singapore
- Yap Seng Chong
- Department of Obstetrics & Gynaecology, Yong Loo Lin School of Medicine, National University of Singapore
- Sonia Davila
- SingHealth Duke-NUS Institute of Precision Medicine
- Liuh Ling Goh
- Personalized Medicine Service, Tan Tock Seng Hospital
- Eng Sing Lee
- Lee Kong Chian School of Medicine, Nanyang Technological University
- Eleanor Wong
- Genome Institute of Singapore, Agency for Science, Technology and Research
- Tien Yin Wong
- Singapore Eye Research Institute, Singapore National Eye Centre
- SG10K_Health Consortium
- Shyam Prabhakar
- Laboratory of Systems Biology and Data Analytics, Genome Institute of Singapore, Agency for Science, Technology and Research
- Jianjun Liu
- Human Genomics, Genome Institute of Singapore, Agency for Science, Technology and Research
- Ching-Yu Cheng
- Singapore Eye Research Institute, Singapore National Eye Centre
- Birgit Eisenhaber
- Genome Institute of Singapore, Agency for Science, Technology and Research
- Neerja Karnani
- Human Development, Singapore Institute for Clinical Sciences
- Khai Pang Leong
- Personalized Medicine Service, Tan Tock Seng Hospital
- Xueling Sim
- Saw Swee Hock School of Public Health, National University of Singapore
- Khung Keong Yeo
- SingHealth Duke-NUS Institute of Precision Medicine
- John C. Chambers
- Lee Kong Chian School of Medicine, Nanyang Technological University
- E-Shyong Tai
- Saw Swee Hock School of Public Health, National University of Singapore
- Patrick Tan
- SingHealth Duke-NUS Institute of Precision Medicine
- Saumya S. Jamuar
- SingHealth Duke-NUS Institute of Precision Medicine
- Joanne Ngeow
- Cancer Genetics Service, Division of Medical Oncology, National Cancer Centre Singapore
- Weng Khong Lim
- SingHealth Duke-NUS Institute of Precision Medicine
- DOI
- https://doi.org/10.1038/s41467-022-34116-9
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 15
Abstract
Clinically significant genetic variation in Asian populations is under-characterized. Here, the authors show the diversity in prevalence and spectrum of human disease and pharmacogenetic variants in a multi-ethnic Asian population.
